cefaclor

Contraindicated in:

Hypersensitivity to cephalosporins;
Serious hypersensitivity to penicillins.

Use Cautiously in:

Renal impairment ;
History of GI disease, especially colitis;
OB: Has been used safely.

Adv. Reactions/Side Effects ⬆ ⬇

GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, vomiting

Derm: rash, urticaria

Hemat: agranulocytosis, bleeding, eosinophilia, hemolytic anemia, neutropenia

Neuro: SEIZURES(VERY HIGH DOSES)

Misc: ANAPHYLAXIS AND SERUM SICKNESSALLERGIC REACTIONS INCLUDING , superinfection

Interactions ⬆ ⬇

Drug-drug:

Probenecid ↓excretion and ↑ blood levels.
Antacids ↓absorption.

Availability ⬆ ⬇

(Generic available)

Capsules: 250 mg; 500 mg
Extended-release tablets (CD): 375 mg; 500 mg
Oral suspensionstrawberry: 125 mg/5 mL; 187 mg/5 mL; 250 mg/5 mL; 375 mg/5 mL

Route/Dosage ⬆ ⬇

PO (Adults ): Immediate-release—250–500 mg q 8 hr; Extended-release—375–500 mg q 12 hr.
PO (Children >1 mo): 6.7–13.4 mg/kg q 8 hr or 10–20 mg/kg q 12 hr (up to 1 g/day).

Action ⬆ ⬇

Binds to bacterial cell wall membrane, causing cell death.

Therapeutic effects:

Bactericidal action against susceptible bacteria.

Spectrum:

Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens including:
- Haemophilus influenzae,
- Escherichia coli,
- Klebsiella pneumoniae,
- Proteus mirabilis.
Not active against methicillin-resistant staphylococci or enterococci.

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: second generation cephalosporins

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed. Penetration into CSF is poor. Crosses the placenta and enters breast milk in low concentrations.

Metabolism/Excretion: Excreted primarily unchanged by the kidneys.

Half-Life: 30–60 min (↑ in renal impairment).

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
PO	rapid	30–60 min	6–12 hr
PO-CD	unknown	unknown	12 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take medication around the clock at evenly spaced times and to finish medication completely, even if feeling better. Take missed doses as soon as possible unless almost time for next dose; do not double doses. Instruct patient to use calibrated measuring device with suspension. Advise patient that sharing of this medication may be dangerous.
Advise patient to report signs of superinfection (furry overgrowth on the tongue, vaginal itching or discharge, loose or foul-smelling stools) and allergy.
Instruct patient to notify health care professional if fever and diarrhea develop, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting health care professional.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0093- Teva Pharmaceuticals USA, Inc.
- 0093-1087- Cefaclor
  - 0093-1087-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0093-1087-01)

50090- A-S Medication Solutions
- 50090-1602- Cefaclor
  - 50090-1602-0- 30 CAPSULE in 1 BOTTLE (50090-1602-0)

50090- A-S Medication Solutions
- 50090-1602- Cefaclor
  - 50090-1602-2- 21 CAPSULE in 1 BOTTLE (50090-1602-2)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-01- 100 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-01)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-05- 500 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-05)

61442- Carlsbad Technology, Inc.
- 61442-171- Cefaclor
  - 61442-171-30- 30 CAPSULE in 1 BOTTLE, PLASTIC (61442-171-30)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-01- 100 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-01)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-05- 500 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-05)

61442- Carlsbad Technology, Inc.
- 61442-172- Cefaclor
  - 61442-172-30- 30 CAPSULE in 1 BOTTLE, PLASTIC (61442-172-30)

81948- Azorian Pharma, LLC
- 81948-6250- Cefaclor
  - 81948-6250-1- 150 mL in 1 BOTTLE (81948-6250-1)

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Indications ⬇

Contraind./Precautions ⬆ ⬇