- IV (Adults ): 1.2 g/m2/day for 5 days; coadminister with mesna. May repeat cycle every 3 wk.
High Alert
Contraindicated in:
WBC count <2000/mm3
;Platelet count <50,000/mm3
;Use Cautiously in:
High ifosfamide dose, hypoalbuminemia, renal impairment, poor performance status, or bulky abdominal-pelvic disease (↑ risk of encephalopathy)
;CV: cardiotoxicity
Derm: alopecia, impaired wound healing
EENT: blurred vision
GI: nausea, vomiting, anorexia, constipation, diarrhea, hepatotoxicity
GU: HEMORRHAGIC CYSTITIS, dysuria, RENAL FAILURE, sterility, urinary incontinence
Hemat: ANEMIA, LEUKOPENIA, THROMBOCYTOPENIA
Local: phlebitis
Neuro: confusion, sedation, dizziness, ENCEPHALOPATHY, extrapyramidal symptoms, hallucinations, psychosis, SEIZURES
Drug-drug:
Drug-Food:
Absorption: IV administration results in complete bioavailability.
Distribution: Minimally distributed to tissues.
Half-Life: 15 hr.
Emphasize need for adequate fluid intake throughout therapy and to void frequently to ↓ bladder irritation. Notify health care provider immediately if blood in the urine occurs.
Instruct patient to notify health care provider promptly if fever; chills; cough; hoarseness; sore throat; signs of infection; lower back or side pain; painful or difficult urination; bleeding gums; bruising; petechiae; blood in urine, stool, or emesis; or confusion occurs.
Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor and to avoid falls. Patient should also be cautioned not to drink alcoholic beverages or take products containing aspirin or NSAIDs, as these may cause GI hemorrhage.
Advise patient to notify health care provider immediately if confusion, sedation, hallucination, blurred vision, psychotic behavior, extrapyramidal symptoms, urinary incontinence, or seizure occur.
NDC Code
