ra-LOX-i-feen
REMS
Contraindicated in:
History of thromboembolic events
.Use Cautiously in:
History of stroke or transient ischemic attack
;CV: DEEP VEIN THROMBOSIS, MI
Derm: hot flush
EENT: retinal vein thrombosis
MS: leg cramps
Neuro: STROKE
Resp: PULMONARY EMBOLISM
Drug-drug:
Therapeutic Classification: bone resorption inhibitors
Pharmacologic Classification: selective estrogen receptor modulators
Absorption: Although well absorbed (>60%), after oral administration, extensive first-pass metabolism results in 2% bioavailability.
Distribution: Extensively distributed to tissues.
Protein Binding: 95%.
Half-Life: 27.7 hr.
Instruct patient to notify health care provider immediately if leg pain, redness, or ↑ warmth in lower leg; swelling of legs, hands, or feet; sudden chest pain; shortness of breath or coughing up blood; or sudden change in vision occur.
NDC Code