High Alert
Contraindicated in:
Hypersensitivity to docetaxel, paclitaxel, or medications formulated with polysorbate 80
;Neutrophil count <1500/mm3
;Hepatic impairment (serum bilirubin > upper limit of normal [ULN], ALT and/or AST >1.5 times ULN, with alkaline phosphatase >2.5 times ULN) (↑ risk of serious adverse reactions)
;Use Cautiously in:
CV: peripheral edema
Derm: alopecia, edema, rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP), dermatitis, desquamation, erythema, nail disorders, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: cystoid macular edema
GI: diarrhea, nausea, stomatitis, vomiting, ASCITES, ENTEROCOLITIS, NEUTROPENIC COLITIS
GU: ↓fertility (men), amenorrhea
Hemat: anemia, leukopenia, thrombocytopenia
Local: injection site reactions
MS: myalgia, arthralgia
Neuro: fatigue, weakness, alcohol intoxication, neurosensory deficits, peripheral neuropathy
Resp: ACUTE RESPIRATORY DISTRESS SYNDROME, bronchospasm, dyspnea, INTERSTITIAL LUNG DISEASE, PULMONARY EDEMA, PULMONARY FIBROSIS
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), MALIGNANCY (INCLUDING LEUKEMIAS, MYELODYSPLASTIC SYNDROME, NON-HODGKIN LYMPHOMA, AND RENAL CANCER), tumor lysis syndrome
Drug-drug:
Locally Advanced or Metastatic Breast Cancer
Adjuvant Treatment of Operable Node-Positive Breast Cancer
Non-Small Cell Lung Cancer, Metastatic Castration-Resistant Prostate Cancer, or Advanced Gastric Adenocarcinoma
Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 116 hr.
Instruct patient to report symptoms of hypersensitivity reactions (trouble breathing; sudden swelling of face, lips, tongue, or throat; trouble swallowing; hives; rash; redness all over body) to health care provider immediately.
Advise patient to notify health care provider if fever >101°F; chills; sore throat; signs of infection; bleeding gums; bruising; petechiae; or blood in urine, stool, or emesis occur. Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor.
Instruct patient to notify health care provider if signs of fluid retention (peripheral edema in the lower extremities, weight gain, dyspnea), colitis (abdominal pain or tenderness, diarrhea, with or without fever), yellow skin, weakness, paresthesia, gait disturbances, swelling of the feet, or joint or muscle aches occur.
NDC Code
