- PO (Adults and Children >14 yr): If used alone, start with 1200 mg/day in 3–4 divided doses. May be ↑ by 600 mg/day at 2-wk intervals up to a total of 3600 mg. If converting from other agents, start with 1200 mg/day in 3–4 divided doses and ↓ other anticonvulsants by 1/3. At wk 2, ↑ felbamate to 2400 mg/day in 3–4 divided doses and ↓ other anticonvulsants by up to 1/3 of their original dosage. At wk 3, ↑ felbamate to 3600 mg/day in 3–4 divided doses while continuing to ↓ doses of other anticonvulsants. If using as adjunctive therapy (with other agents), start with 1200 mg/day in 3–4 divided doses, ↓ doses of other anticonvulsants by 20%. ↑ dose at weekly intervals by 1200 mg/day to 3600 mg/day. ↓ doses of other anticonvulsants as necessary.
- PO (Children ): As adjunctive therapy, start at 15 mg/kg/day in 3–4 divided doses, ↓ the dose of other anticonvulsants by 20%. ↑ dosage by 15 mg/kg/day (not to exceed 3600 mg/day) at weekly intervals to 45 mg/kg/day. ↓ doses of other anticonvulsants as necessary.
