Binds to and activates the aryl hydrocarbon receptor, which regulates cytokine and skin-barrier-protein expression and antioxidant activity. The specific mechanism for its effects in psoriasis is not known.
Metabolism/Excretion: Primarily metabolized by the liver.
Half-Life: Unknown.
Time/Action Profile⬆⬇
(plaque reduction)
ROUTE
ONSET
PEAK
DURATION
Topical
unknown
unknown
unknown
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication. Advise patient to apply cream as directed; wash hands after use unless cream is applied to hands. Advise patient to read Patient Information before starting therapy.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
