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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema of the hands and feet

Endo: hyperglycemia, hypothyroidism, insulin resistance

GI: PANCREATITIS

Local: pain at injection site, local lipoatrophy or lipodystrophy with subcutaneous use

MS: arthralgia

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Genotropin, Genotropin MiniQuick

Action ⬆ ⬇

  • Produce growth (skeletal and cellular).
  • Metabolic actions include:
    • Increased protein synthesis,
    • Increased carbohydrate metabolism,
    • Lipid mobilization,
    • Retention of sodium, phosphorus, and potassium.
  • Somatropin has the same amino acid sequence as naturally occurring growth hormone and is produced by recombinant DNA techniques.
  • Growth hormone enhances GI tract mucosal transport of water, electrolytes and nutrients.
Therapeutic effects:
  • Increased skeletal growth in children with growth hormone deficiency.
  • Replacement of somatropin in deficient adults.
  • Increased bone density in adult growth hormone–deficient patients.

Classifications ⬆ ⬇

Therapeutic Classification: hormones

Pharmacologic Classification: growth hormones

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (80%).

Distribution: Localize to highly perfused organs (liver, kidneys).

Metabolism/Excretion: Broken down in renal cells to amino acids that are recirculated; some liver metabolism.

Half-Life: Subcut—3.8 hr.

Canadian Brand Names ⬆ ⬇

Genotropin GoQuick

Time/Action Profile ⬆ ⬇

(growth)

ROUTEONSETPEAKDURATION
IM, subcutwithin 3 mounknown12–48 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

soe-ma-TROE-pin

Code ⬆

NDC Code