Risk of irritation ↑ by other topical skin-care products (aftershave, cover-up, make-up, perfumes, colognes).
Availability⬆⬇
(Generic available)
Cream: 0.1%
Gel: 0.1%; 0.3% OTC
Solution: 0.1%
Route/Dosage⬆⬇
(Adults and Children ≥12 yr): Apply once daily at bedtime.
US Brand Names⬆⬇
Differin
Action⬆⬇
Binds to retinoic acid nuclear receptors resulting in decreased microcomedone formation.
Therapeutic effects:
Reduction in inflammatory and noninflammatory acne lesions.
Classifications⬆⬇
Therapeutic Classification: antiacne agents
Pharmacologic Classification: retinoids
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption occurs with limited surface-area application.
Distribution: Unknown.
Metabolism/Excretion: Excreted via the biliary route.
Half-Life: Unknown.
Time/Action Profile⬆⬇
(improved skin appearance)
ROUTE
ONSET
PEAK
DURATION
Topical
8–12 wk
unknown
unknown
Patient/Family Teaching⬆⬇
Instruct patient on correct technique for application of cream.
Explain to patient that a temporary worsening of acne may occur at beginning of therapy.
Caution patient to use sunscreen and protective clothing to prevent photosensitivity reactions. Health care professional should be consulted about sunscreen, as some sunscreens may worsen acne.
Rep: Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Pronunciation⬆⬇
a-DAP-a-leen
Code⬆
NDC Code
0168- E. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
0168-0424- Adapalene
0168-0424-46- 1 TUBE in 1 CARTON (0168-0424-46) / 45 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-00- 1 TUBE in 1 BLISTER PACK (0299-4910-00) / 2 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-10- 1 BOTTLE, PUMP in 1 CARTON (0299-4910-10) / 15 g in 1 BOTTLE, PUMP
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-15- 1 TUBE in 1 CARTON (0299-4910-15) / 15 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-40- 1 BOTTLE, PUMP in 1 CARTON (0299-4910-40) / 45 g in 1 BOTTLE, PUMP
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-45- 1 TUBE in 1 CARTON (0299-4910-45) / 45 g in 1 TUBE
