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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: angina, arrhythmias, edema, flushing, hypotension

EENT: blurred vision

GI: abdominal discomfort, belching, bloating, diarrhea, dyspepsia, flatus, nausea, vomiting

Neuro: agitation, dizziness, drowsiness, headache, insomnia, nervousness, tremor

Resp: dyspnea

Misc: ANAPHYLAXIS

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

TRENtal

Action ⬆ ⬇

  • Increases the flexibility of RBCs by increasing levels of cyclic adenosine monophosphate (cAMP).
  • Decreases blood viscosity by inhibiting platelet aggregation and decreasing fibrinogen.
Therapeutic effects:
  • Increased blood flow.

Classifications ⬆ ⬇

Therapeutic Classification: blood viscosity reducing agent

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration; food ↑ absorption.

Distribution: Bound to RBC membrane. Enters breast milk.

Metabolism/Excretion: Metabolized by RBCs and the liver.

Half-Life: 25–50 min.

Time/Action Profile ⬆ ⬇

(improvement in blood flow)

ROUTEONSETPEAKDURATION
PO2–4 wk8 wk8 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

pen-tox-IF-i-lin

Code ⬆

NDC Code