kloe-MIP-ra-meen
Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation especially during dose early treatment or dose adjustment; risk may be greater in children or adolescents
;CV: ECG changes, ARRHYTHMIAS, orthostatic hypotension
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMATIC SYMPTOMS (DRESS), dry skin, photosensitivity
EENT: blurred vision, dry eyes, vestibular disorder
Endo: gynecomastia, syndrome of inappropriate antidiuretic syndrome (SIADH)
F and E: hyponatremia
GI: vomiting, constipation, dry mouth, nausea, eructation
GU: male sexual dysfunction, urinary retention
Hemat: anemia
MS: muscle weakness
Neuro: sedation, weakness, aggressive behavior, extrapyramidal reactions, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS
Misc: hyperthermia
Drug-drug:
Drug-Natural Products:
Drug-Food:
Therapeutic Classification: antiobsessive agents
Pharmacologic Classification: tricyclic antidepressants
Absorption: Well absorbed from the GI tract.
Distribution: Widely distributed to tissues.
Protein Binding: ≥90%.
Half-Life: 21–31 hr.
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior.
NDC Code