TRAZ-oh-done
Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children
;CV: hypotension, arrhythmias, chest pain, hypertension, palpitations, QT interval prolongation, tachycardia
Derm: rash
EENT: blurred vision, tinnitus
F and E: hyponatremia, SIADH
GI: dry mouth, constipation, diarrhea, excess salivation, flatulence, nausea, vomiting
GU: erectile dysfunction, hematuria, priapism, urinary frequency
Hemat: anemia, leukopenia
MS: myalgia
Neuro: drowsiness, confusion, dizziness, dysgeusia, fatigue, hallucinations, headache, insomnia, nightmares, slurred speech, SUICIDAL THOUGHTS/BEHAVIORS, syncope, tremor, weakness
Drug-drug:
Drug-Natural Products:
Depression
Insomnia
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: 89–95%.
Half-Life: 5–9 hr.
Advise patient family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior occur.
NDC Code
