minoxidil (systemic)

section name header

Indications ⬇

REMS

Severe symptomatic hypertension or hypertension associated with end-organ damage that has failed to respond to combinations of more conventional therapy.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity;
Pheochromocytoma.

Use Cautiously in:

Recent MI;
Severe renal impairment (can be used in moderate renal impairment);
Geri: May be more sensitive to effects; consider age-related ↓ in body mass and hepatic/renal/cardiovascular function;
OB: Neonatal hypertrichosis has been reported; use only if potential benefit justifies potential risk to fetus;
Lactation: Safety not established.

Adv. Reactions/Side Effects ⬆ ⬇

CV: ECG changes (alteration in T waves), tachycardia, HF, angina, pericardial effusion

Derm: hypertrichosis, pigment changes, rash

Endo: gynecomastia, menstrual irregularities

F and E: sodium and water retention

GI: nausea

Neuro: headache

Resp: PULMONARY EDEMA

Misc: intermittent claudication

Interactions ⬆ ⬇

Drug-drug:

Additive hypotensive effects with other antihypertensives, acute ingestion of alcohol, or nitrates.
NSAIDs may ↓ the antihypertensive effectiveness of minoxidil.

Availability ⬆ ⬇

(Generic available)

Tablets: 2.5 mg; 10 mg

Route/Dosage ⬆ ⬇

PO (Adults and Children >12 yr): 5 mg once daily or in 2 divided doses; may double at 3-day intervals; usual range 10–40 mg/day (for rapid control with careful monitoring, doses may be adjusted q 6 hr; up to 100 mg/day has been used).
PO (Children <12 yr): 0.2 mg/kg/day (5 mg maximum) as a single dose or 2 divided doses; may be gradually ↑ at 3-day intervals in increments of 50–100% until response is obtained; usual range 0.25–1 mg/kg/day (for rapid control, doses may be adjusted q 6 hr; not to exceed 50 mg/day).

Action ⬆ ⬇

Directly relaxes vascular smooth muscle, probably by inhibiting the enzyme phosphodiesterase. Results in vasodilation, which is more pronounced in arterioles than veins.

Therapeutic effects:

Lowering of BP.

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives

Pharmacologic Classification: vasodilators

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed; enters breast milk.

Metabolism/Excretion: 90% metabolized by the liver.

Half-Life: 4.2 hr.

Canadian Brand Names ⬆ ⬇

Loniten

Time/Action Profile ⬆ ⬇

(antihypertensive effect)

ROUTE	ONSET	PEAK	DURATION
PO	30 min	2–3 hr	2–5 days

Patient/Family Teaching ⬆ ⬇

Emphasize the importance of continuing to take this medication, even if feeling well. Instruct patient to take medication at the same time each day. Take missed doses as soon as remembered if within a few hours; otherwise, omit dose and return to regular dose schedule. Do not double doses. Advise patient not to discontinue minoxidil or other antihypertensive medications without consulting health care professional. Minoxidil helps control but does not cure hypertension.
- Encourage patient to comply with additional interventions for hypertension (weight reduction, low-sodium diet, smoking cessation, moderation of alcohol consumption, regular exercise, and stress management).
- Instruct patient and family on proper technique for weekly pulse and BP monitoring. Advise them to report significant changes to health care professional, who should also be notified if resting pulse increases more than 20 bpm above baseline.
- Advise patient to check weight daily and to notify health care professional of rapid weight gain of >5 lb or if signs of fluid retention occur.
- Caution patient to change positions slowly to minimize orthostatic hypotension.
- Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications, especially cough, cold, or allergy remedies or herbal products.
- Inform patient that depilatory creams may minimize increased hair growth. This is temporary and is reversible within 1–6 mo following discontinuation of minoxidil.
- Advise patient to notify health care professional if unusual swelling of face, extremities, or abdomen; difficulty breathing, especially when lying down; new or aggravated angina; severe indigestion; dizziness or fainting occurs.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

mi-NOX-i-dill

Code ⬆

NDC Code

0009- Pharmacia and Upjohn Company LLC
- 0009-5056-
  - 0009-5056-35- 1 BAG in 1 DRUM (0009-5056-35) / 35 kg in 1 BAG

0009- Pharmacia and Upjohn Company LLC
- 0009-5230-
  - 0009-5230-02- 1 BAG in 1 DRUM (0009-5230-02) / 55 kg in 1 BAG

0009- Pharmacia and Upjohn Company LLC
- 0009-5230-
  - 0009-5230-03- 3 BAG in 1 DRUM (0009-5230-03) / 10 kg in 1 BAG (0009-5230-10)

0113- L. Perrigo Company
- 0113-0798- Good Sense Hair Regrowth Treatment for Men
  0113-0798-30- 3 BOTTLE in 1 CARTON (0113-0798-30) / 60 mL in 1 BOTTLE

0113- L. Perrigo Company
- 0113-0798- Good Sense Hair Regrowth Treatment for Men
  - 0113-0798-40- 6 BOTTLE in 1 CARTON (0113-0798-40) / 60 mL in 1 BOTTLE

0113- L. Perrigo Company
- 0113-1032- Good Sense Hair Regrowth Treatment
  - 0113-1032-30- 3 BOTTLE, DROPPER in 1 CARTON (0113-1032-30) / 60 mL in 1 BOTTLE, DROPPER

0113- L. Perrigo Company
- 0113-1129- Good Sense Hair Regrowth Treatment
  - 0113-1129-06- 6 CAN in 1 CARTON (0113-1129-06) / 60 g in 1 CAN

0113- L. Perrigo Company
- 0113-5129- minoxidil
  - 0113-5129-01- 60 g in 1 CAN (0113-5129-01)

0113- L. Perrigo Company
- 0113-5129- minoxidil
  - 0113-5129-06- 6 CAN in 1 CARTON (0113-5129-06) / 60 g in 1 CAN

0363- Walgreen Company
- 0363-0032- hair regrowth treatment
  - 0363-0032-16- 1 BOTTLE in 1 CARTON (0363-0032-16) / 60 mL in 1 BOTTLE

0363- Walgreen Company
- 0363-0032- hair regrowth treatment
  - 0363-0032-30- 3 BOTTLE in 1 CARTON (0363-0032-30) / 60 mL in 1 BOTTLE

0363- Walgreen Company
- 0363-0703- hair regrowth treatment
  - 0363-0703-16- 1 BOTTLE, DROPPER in 1 CARTON (0363-0703-16) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreen Company
- 0363-0703- hair regrowth treatment
  - 0363-0703-30- 3 BOTTLE, DROPPER in 1 CARTON (0363-0703-30) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreen Company
- 0363-9090- Minoxidil (For Men)
  - 0363-9090-01- 1 CAN in 1 CARTON (0363-9090-01) / 60 g in 1 CAN

0363- Walgreen Company
- 0363-9090- Minoxidil (For Men)
  - 0363-9090-03- 3 CAN in 1 CARTON (0363-9090-03) / 60 g in 1 CAN

0363- Walgreen Company
- 0363-9091- Minoxidil (For Women)
  - 0363-9091-01- 1 CAN in 1 CARTON (0363-9091-01) / 60 g in 1 CAN

0363- Walgreen Company
- 0363-9091- Minoxidil (For Women)
  - 0363-9091-03- 3 CAN in 1 CARTON (0363-9091-03) / 60 g in 1 CAN

0363- Walgreens
- 0363-9970- Minoxidil
  - 0363-9970-02- 1 BOTTLE, DROPPER in 1 CARTON (0363-9970-02) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreens
- 0363-9970- Minoxidil
  - 0363-9970-06- 3 BOTTLE, DROPPER in 1 CARTON (0363-9970-06) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreens
- 0363-9971- Minoxidil
  - 0363-9971-02- 1 BOTTLE, DROPPER in 1 CARTON (0363-9971-02) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreens
- 0363-9971- Minoxidil
  - 0363-9971-06- 3 BOTTLE, DROPPER in 1 BOTTLE (0363-9971-06) / 60 mL in 1 BOTTLE, DROPPER

0363- Walgreens
- 0363-9973- Minoxidil
  - 0363-9973-06- 3 BOTTLE, DROPPER in 1 CARTON (0363-9973-06) / 60 mL in 1 BOTTLE, DROPPER

0591- Actavis Pharma, Inc.
- 0591-5642-
  - 0591-5642-00- 91000 TABLET in 1 BAG (0591-5642-00)

0591- Actavis Pharma, Inc.
- 0591-5642- Minoxidil
  0591-5642-01- 100 TABLET in 1 BOTTLE, PLASTIC (0591-5642-01)

0591- Actavis Pharma, Inc.
- 0591-5642- Minoxidil
  - 0591-5642-05- 500 TABLET in 1 BOTTLE, PLASTIC (0591-5642-05)

0591- Actavis Pharma, Inc.
- 0591-5642-
  - 0591-5642-77- 109092 TABLET in 1 CONTAINER (0591-5642-77)

0591- Actavis Pharma, Inc.
- 0591-5643-
  0591-5643-00- 91000 TABLET in 1 BAG (0591-5643-00)

0591- Actavis Pharma, Inc.
- 0591-5643- Minoxidil
  0591-5643-01- 100 TABLET in 1 BOTTLE, PLASTIC (0591-5643-01)

0591- Actavis Pharma, Inc.
- 0591-5643- Minoxidil
  - 0591-5643-05- 500 TABLET in 1 BOTTLE, PLASTIC (0591-5643-05)

0591- Actavis Pharma, Inc.
- 0591-5643-
  - 0591-5643-77- 109092 TABLET in 1 CONTAINER (0591-5643-77)

10695- Willow Birch Pharma, Inc
- 10695-149-
  10695-149-70- 25 kg in 1 DRUM (10695-149-70)

11673- TARGET Corporation
- 11673-157- Minoxidil (For Men)
  11673-157-03- 3 CAN in 1 CARTON (11673-157-03) / 60 g in 1 CAN (11673-157-01)

11673- TARGET Corporation
- 11673-157- Minoxidil (For Men)
  - 11673-157-09- 3 CAN in 1 CARTON (11673-157-09) / 60 g in 1 CAN (11673-157-01)

11673- TARGET Corporation
- 11673-158- Minoxidil (For Women)
  - 11673-158-04- 1 CAN in 1 CARTON (11673-158-04) / 60 g in 1 CAN

11673- TARGET Corporation
- 11673-158- Minoxidil (For Women)
  - 11673-158-08- 2 CAN in 1 CARTON (11673-158-08) / 60 g in 1 CAN

11673- Target Corporation
- 11673-189- up and up hair regrowth treatment for women
  - 11673-189-30- 3 BOTTLE in 1 CARTON (11673-189-30) / 60 mL in 1 BOTTLE (11673-189-16)

11673- Target Corporation
- 11673-317- up and up hair regrowth treatment for men
  - 11673-317-30- 3 BOTTLE, DROPPER in 1 CARTON (11673-317-30) / 60 mL in 1 BOTTLE, DROPPER (11673-317-16)

11673- Target Corporation
- 11673-382- up and up hair regrowth treatment for women
  - 11673-382-16- 1 BOTTLE in 1 CARTON (11673-382-16) / 60 mL in 1 BOTTLE

11673- Target Corporation
- 11673-382- up and up hair regrowth treatment for women
  - 11673-382-30- 3 BOTTLE in 1 CARTON (11673-382-30) / 60 mL in 1 BOTTLE

11673- Target Corporation
- 11673-431- up and up hair regrowth treatment for women
  - 11673-431-01- 1 CAN in 1 CARTON (11673-431-01) / 60 g in 1 CAN

11673- Target Corporation
- 11673-431- up and up hair regrowth treatment for women
  - 11673-431-02- 2 CAN in 1 CARTON (11673-431-02) / 60 g in 1 CAN

11673- Target Corporation
- 11673-707- up and up hair regrowth treatment for men
  - 11673-707-03- 3 CAN in 1 CARTON (11673-707-03) / 60 g in 1 CAN (11673-707-01)

11673- Target Corporation
- 11673-919- up and up hair regrowth treatment for women
  - 11673-919-30- 3 BOTTLE, DROPPER in 1 CARTON (11673-919-30) / 60 mL in 1 BOTTLE, DROPPER (11673-919-16)

11822- Rite Aid Corporation
- 11822-0114- Minoxidil
  - 11822-0114-1- 60 g in 1 CAN (11822-0114-1)

11822- Rite Aid Corporation
- 11822-0114- Minoxidil
  - 11822-0114-2- 2 CAN in 1 PACKAGE (11822-0114-2) / 60 g in 1 CAN

11822- Rite Aid Corporation
- 11822-0115- Minoxidil
  - 11822-0115-1- 1 CAN in 1 PACKAGE (11822-0115-1) / 60 g in 1 CAN

11822- Rite Aid Corporation
- 11822-0115- Minoxidil
  - 11822-0115-3- 3 CAN in 1 PACKAGE (11822-0115-3) / 60 g in 1 CAN

11822- Rite Aid Corporation
- 11822-0202- Minoxidil
  - 11822-0202-1- 3 BOTTLE in 1 CARTON (11822-0202-1) / 60 mL in 1 BOTTLE

11822- Rite Aid Corporation
- 11822-0798- minoxidil
  - 11822-0798-1- 3 BOTTLE in 1 CARTON (11822-0798-1) / 60 mL in 1 BOTTLE

11822- Rite Aid Corporation
- 11822-0798- minoxidil
  - 11822-0798-2- 1 BOTTLE in 1 CARTON (11822-0798-2) / 60 mL in 1 BOTTLE

11822- Rite Aid Corporation
- 11822-1260- hair regrowth treatment
  - 11822-1260-0- 1 BOTTLE, DROPPER in 1 CARTON (11822-1260-0) / 60 mL in 1 BOTTLE, DROPPER

17337- Olon SpA
- 17337-0027-
  - 17337-0027-1- 25 kg in 1 DRUM (17337-0027-1)

21130- Safeway
- 21130-273- signature care hair regrowth treatment
  21130-273-16- 1 BOTTLE in 1 CARTON (21130-273-16) / 60 mL in 1 BOTTLE

21130- Safeway
- 21130-273- signature care hair regrowth treatment
  - 21130-273-30- 3 BOTTLE in 1 CARTON (21130-273-30) / 60 mL in 1 BOTTLE

21130- Safeway
- 21130-611- hair regrowth treatment
  - 21130-611-16- 1 BOTTLE in 1 CARTON (21130-611-16) / 60 mL in 1 BOTTLE

21130- Safeway
- 21130-611- hair regrowth treatment
  - 21130-611-30- 3 BOTTLE in 1 CARTON (21130-611-30) / 60 mL in 1 BOTTLE

21130- Safeway
- 21130-750- Signature Care Hair Regrowth Treatment for men
  - 21130-750-01- 60 g in 1 CAN (21130-750-01)

21130- Safeway
- 21130-750- Signature Care Hair Regrowth Treatment for men
  - 21130-750-03- 3 CAN in 1 CARTON (21130-750-03) / 60 g in 1 CAN

21130- Safeway
- 21130-819- signature care hair regrowth treatment
  - 21130-819-16- 1 BOTTLE, DROPPER in 1 CARTON (21130-819-16) / 60 mL in 1 BOTTLE, DROPPER

21130- Safeway
- 21130-819- signature care hair regrowth treatment
  - 21130-819-30- 3 BOTTLE, DROPPER in 1 CARTON (21130-819-30) / 60 mL in 1 BOTTLE, DROPPER

30142- Kroger Company
- 30142-294- hair regrowth treatment for men
  - 30142-294-01- 1 CAN in 1 CARTON (30142-294-01) / 60 g in 1 CAN

30142- Kroger Company
- 30142-294- hair regrowth treatment for men
  - 30142-294-03- 3 CAN in 1 CARTON (30142-294-03) / 60 g in 1 CAN

30142- Kroger Company
- 30142-632- hair regrowth treatment
  - 30142-632-30- 3 BOTTLE, DROPPER in 1 CARTON (30142-632-30) / 60 mL in 1 BOTTLE, DROPPER (30142-632-16)

30142- Kroger Company
- 30142-719- hair regrowth treatment
  - 30142-719-02- 2 CAN in 1 CARTON (30142-719-02) / 60 g in 1 CAN

37808- H E B
- 37808-833- minoxidil
  - 37808-833-16- 1 BOTTLE, DROPPER in 1 CARTON (37808-833-16) / 60 mL in 1 BOTTLE, DROPPER

37808- H E B
- 37808-833- minoxidil
  - 37808-833-30- 3 BOTTLE, DROPPER in 1 CARTON (37808-833-30) / 60 mL in 1 BOTTLE, DROPPER

38779- Medisca Inc.
- 38779-0574-
  - 38779-0574-1- 10 g in 1 VIAL (38779-0574-1)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-2- 5 g in 1 BOTTLE, GLASS (38779-0574-2)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-3- 5000 g in 1 PAIL (38779-0574-3)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-4- 25 g in 1 JAR (38779-0574-4)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-5- 100 g in 1 JAR (38779-0574-5)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-6- 20000 g in 1 DRUM (38779-0574-6)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-7- 25000 g in 1 DRUM (38779-0574-7)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-8- 500 g in 1 JAR (38779-0574-8)

38779- Medisca Inc.
- 38779-0574-
  38779-0574-9- 1000 g in 1 JAR (38779-0574-9)

40700- Icrom S.r.l.
- 40700-0008-
  40700-0008-0- 25 kg in 1 DRUM (40700-0008-0)

41250- Meijer Distribution Inc
- 41250-294- hair regrowth treatment
  41250-294-01- 1 CAN in 1 CARTON (41250-294-01) / 60 g in 1 CAN

41250- Meijer Distribution Inc
- 41250-294- hair regrowth treatment
  - 41250-294-03- 3 CAN in 1 CARTON (41250-294-03) / 60 g in 1 CAN

41250- Meijer, Inc.
- 41250-428- hair regrowth treatment
  - 41250-428-30- 3 BOTTLE, DROPPER in 1 CARTON (41250-428-30) / 60 mL in 1 BOTTLE, DROPPER (41250-428-16)

41250- Meijer Distribution Inc
- 41250-749- hair regrowth treatment
  - 41250-749-01- 1 CAN in 1 CARTON (41250-749-01) / 60 g in 1 CAN

42291- AvKARE
- 42291-618- MINOXIDIL
  - 42291-618-01- 100 TABLET in 1 BOTTLE (42291-618-01)

42291- AvKARE
- 42291-619- MINOXIDIL
  - 42291-619-01- 100 TABLET in 1 BOTTLE (42291-619-01)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-342- MINOXIDIL
  - 43353-342-09- 9000 TABLET in 1 BOTTLE (43353-342-09)

49035- Wal-Mart Stores Inc
- 49035-294- equate hair regrowth treatment
  - 49035-294-01- 1 CAN in 1 CARTON (49035-294-01) / 60 g in 1 CAN

49035- Wal-Mart Stores Inc
- 49035-294- equate hair regrowth treatment
  - 49035-294-03- 3 CAN in 1 CARTON (49035-294-03) / 60 g in 1 CAN

49035- Wal-Mart Stores Inc
- 49035-746- equate hair regrowth treatment
  - 49035-746-16- 1 BOTTLE, DROPPER in 1 CARTON (49035-746-16) / 60 mL in 1 BOTTLE, DROPPER

49035- Wal-Mart Stores Inc
- 49035-746- equate hair regrowth treatment
  - 49035-746-30- 3 BOTTLE, DROPPER in 1 CARTON (49035-746-30) / 60 mL in 1 BOTTLE, DROPPER

49035- Wal-Mart Stores Inc
- 49035-905- equate hair regrowth treatment
  - 49035-905-01- 1 CAN in 1 CARTON (49035-905-01) / 60 g in 1 CAN

49035- Wal-Mart Stores Inc
- 49035-905- equate hair regrowth treatment
  - 49035-905-06- 6 CAN in 1 CARTON (49035-905-06) / 60 g in 1 CAN

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  - 49452-4780-1- 5 g in 1 BOTTLE (49452-4780-1)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-2- 25 g in 1 BOTTLE (49452-4780-2)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-3- 100 g in 1 BOTTLE (49452-4780-3)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-4- 1000 g in 1 BOTTLE (49452-4780-4)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-5- 5000 g in 1 PAIL (49452-4780-5)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-6- 1 g in 1 BOTTLE (49452-4780-6)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-7- 500 g in 1 BOTTLE (49452-4780-7)

49452- Spectrum Laboratory Products, Inc.
- 49452-4780-
  49452-4780-8- 25000 g in 1 DRUM (49452-4780-8)

49884- Endo USA, Inc.
- 49884-256- Minoxidil
  49884-256-01- 100 TABLET in 1 BOTTLE (49884-256-01)

49884- Endo USA, Inc.
- 49884-257- Minoxidil
  - 49884-257-01- 100 TABLET in 1 BOTTLE (49884-257-01)

49884- Endo USA, Inc.
- 49884-257- Minoxidil
  - 49884-257-05- 500 TABLET in 1 BOTTLE (49884-257-05)

50663- HENKEL US OPERATIONS CORPORATION
- 50663-395- ZOTOS PROFESSIONAL Nutri for Women 2% Minoxidil Topical Solution
  - 50663-395-00- 1 BOTTLE, DROPPER in 1 BOX (50663-395-00) / 60 mL in 1 BOTTLE, DROPPER