- Note: Use lower doses (½ of those listed) in patients who are sodium and water depleted due to diuretics.
Hypertension
- PO (Adults and Adolescents): 12.5–25 mg 2–3 times daily; may be ↑ at 1–2 wk intervals up to 150 mg 3 times daily (initiate therapy with 6.25–12.5 mg 2–3 times daily in patients receiving diuretics).
- PO (Adults ): 25 mg 3 times daily (6.25–12.5 mg 3 times daily in patients who have been vigorously diuresed); titrate up to target dose of 50 mg 3 times daily (max dose = 450 mg/day).
- PO (Children ): 0.3–0.5 mg/kg 3 times daily; titrate up to a maximum of 6 mg/kg/day in 2–4 divided doses; Older Children: 6.25–12.5 mg every 12–24 hr; titrate up to a maximum of 6 mg/kg/day in 2–4 divided doses.
- PO (Infants ): 0.15–0.3 mg/kg; titrate up to a maximum of 6 mg/kg/day in 1–4 divided doses.
- PO (Neonates ): 0.05–0.1 mg/kg every 8–24 hr; may ↑ as needed up to 0.5 mg/kg every 6–24 hr; Premature neonates: 0.01 mg/kg/dose every 8–12 hr.
Left Ventricular Dysfunction Post–Myocardial Infarction
- PO (Adults ): 6.25-mg test dose, followed by 12.5 mg 3 times daily; may be ↑ up to 50 mg 3 times daily.
Diabetic Nephropathy
- PO (Adults ): 25 mg 3 times daily.
Renal Impairment
- PO (Adults ): CCr 10–50 mL/min: Administer 75% of dose; CCr <10 mL/min: Administer 50% of dose.
