al-PRAY-zoe-lam
Contraindicated in:
Use Cautiously in:
Derm: rash
EENT: blurred vision
GI: constipation, diarrhea, nausea, vomiting, weight gain
Neuro: dizziness, drowsiness, lethargy, confusion, depression, hangover, headache, paradoxical excitation
Misc:
physical dependence
,psychological dependence
, toleranceDrug-drug:
Use with opioids or other CNS depressants, including other benzodiazepines, nonbenzodiazepine sedative/hypnotics, anxiolytics, general anesthetics, muscle relaxants, antipsychotics, and alcohol, may cause profound sedation, respiratory depression, coma, and death; reserve concurrent use for when alternative treatment options are inadequate.
Drug-Natural Products:
Drug-Food:
Anxiety
Absorption: Well absorbed (90%) from the GI tract; absorption is slower with extended-release tablets.
Distribution: Widely distributed; crosses blood-brain barrier. Accumulation is minimal.
Half-Life: 12–15 hr.
Caution patient not to stop taking alprazolam without consulting health care provider. Abrupt withdrawal may cause sweating, vomiting, muscle cramps, tremors, and seizures; may be life-threatening.
Advise patient to avoid the use of alcohol or other CNS depressants, including opioids, concurrently with alprazolam; may cause respiratory depression and overdose. Instruct patient to consult health care provider before taking Rx, OTC, or herbal products concurrently with this medication, especially St. John's wort.
Advise patient that alprazolam is a drug with known abuse potential. Protect it from theft, and never give to anyone other than the individual for whom it was prescribed. Store out of sight and reach of children, and in a location not accessible by others.
NDC Code
