becaplermin

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: erythematous rash at application site

Misc: MALIGNANCY

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

(Adults and Children ≥16 yr): Length of gel in inches from 15- or 7.5-g tube = length × width of ulcer area × 0.6; from the 2-g tube = length × width of ulcer area × 1.3. Length of gel in centimeters from 15- or 7.5-g tube = length × width of ulcer area ÷ 4; from the 2-g tube = length × width of ulcer area ÷ 2; for 12 hr each day.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Promotes chemotaxis of cells involved in wound repair and enhances formation of granulation tissue.

Therapeutic effects:

Classifications ⬆ ⬇

Therapeutic Classification: wound/ulcer/decubiti healing agent

Pharmacologic Classification: platelet derived growth factors

Pharmacokinetics ⬆ ⬇

Absorption: Minimal absorption (<3%).

Distribution: Action is primarily local.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(improvement in ulcer healing)

ROUTE	ONSET	PEAK	DURATION
Topical	within 10 wk	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient on proper technique for application. Wash hands before applying gel and use cotton swab or tongue depressor to aid in application. Tip of tube should not come in contact with ulcer or any other surface; recap tightly after each use. Squeeze calculated amount of gel onto a clean, firm, nonabsorbable surface (wax paper). Spread gel with swab or tongue depressor over the ulcer surface in an even layer to the thickness of a dime. Cover with a saline-moistened gauze dressing.
- Do not apply more than calculated amount; has not been shown to be beneficial. If a dose is missed, apply as soon as remembered. If not remembered until next day, skip dose and return to regular dosing schedule. Do not double doses.
- After 12 hr, rinse ulcer gently with saline or water to remove residual gel and cover with saline-moistened gauze.
Emphasize the importance of strict wound care and non–weight-bearing program.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.