High Alert
Contraindicated in:
Use Cautiously in:
Derm: alopecia, rash
EENT: ototoxicity
F and E: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia
GI: abdominal pain, nausea, vomiting
GU: gonadal suppression, nephrotoxicity
Hemat: ANEMIA, LEUKOPENIA, THROMBOCYTOPENIA
Neuro: peripheral neuropathy, weakness
Drug-drug:
Renal Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: Well distributed to tissues.
Protein Binding: Platinum is irreversibly bound to plasma proteins.
Half-Life: Carboplatin: 2.6–5.9 hr (↑ in renal impairment); platinum: 5 days.
Instruct patient to notify health care provider promptly if fever; chills; sore throat; signs of infection; lower back or side pain; difficult or painful urination; bleeding gums; bruising; pinpoint red spots on skin; blood in stools, urine, or emesis; ↑ fatigue, dyspnea, or orthostatic hypotension occurs.
NDC Code
