ee-TOE-doe-lak
Contraindicated in:
Use Cautiously in:
CV: edema, HF, hypertension, MI, palpitations, STROKE
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ecchymoses, EXFOLIATIVE DERMATITIS, flushing, hyperpigmentation, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS), sweating, TOXIC EPIDERMAL NECROLYSIS
EENT: blurred vision, photophobia, tinnitus
GI: dyspepsia, abdominal pain, constipation, diarrhea, dry mouth, flatulence, gastritis, GI BLEEDING, hepatitis, nausea, stomatitis, vomiting
GU: dysuria, renal failure, urinary frequency
Hemat: anemia, prolonged bleeding time, thrombocytopenia
Neuro: depression, dizziness, drowsiness, insomnia, malaise, nervousness, syncope, weakness.
Resp: asthma
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), chills, fever
Drug-drug:
Drug-Natural Products:
Therapeutic Classification: antirheumatics, nonopioid analgesics
Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: >99%.
Half-Life: 6–7 hr (single dose); 7.3 hr (chronic dosing).
(analgesic effect)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO (analgesic) | 0.5 hr | 1–2 hr | 4–12 hr |
| PO (anti-inflammatory) | days–wk | unknown | 6–12 hr‡ |
‡Up to 24 hr as XL (extended-release) tablet.
NDC Code