DES-ven-la-FAX-een
Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation, especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children
;CV: hypertension
Derm: sweating, ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS
EENT: ↑intraocular pressure, mydriasis
Endo: SIADH
F and E: hyponatremia
GI: constipation, nausea, PANCREATITIS
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction
Hemat: BLEEDING
Neuro: anxiety, dizziness, drowsiness, insomnia, headache, NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, teeth grinding, vertigo
Resp: eosinophilic pneumonia, interstitial lung disease
Misc: discontinuation syndrome, SEROTONIN SYNDROME
Drug-drug:
Hepatic Impairment
Renal Impairment
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin and norepinephrine reuptake inhibitors-SSNRIs
Absorption: 80% absorbed following oral administration.
Distribution: Widely distributed to tissues.
Half-Life: 10 hr.
NDC Code