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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

GI: ↑liver enzymes, abdominal distention, diarrhea, flatulence

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Trulance

Action ⬆ ⬇

  • Locally ↑ cyclic guanosine monophosphate concentrations, which ↑ intestinal fluid and accelerates transit time.
Therapeutic effects:
  • Increased frequency of complete spontaneous bowel movements.

Classifications ⬆ ⬇

Therapeutic Classification: laxatives

Pharmacologic Classification: guanylate cyclase-C agonists

Pharmacokinetics ⬆ ⬇

Absorption: Minimally absorbed, action is primarily local.

Distribution: Stays within the GI tract with minimal distribution.

Metabolism/Excretion: Converted to its principal active metabolite within the GI tract. Plecanatide and active metabolite and then degrade in intestinal lumen to smaller peptides and amino acids. Excretion information unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(improvement in symptoms)

ROUTEONSETPEAKDURATION
PO1 wk2–12 wk2 wk‡

‡Following discontinuation.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

ple-KAN-a-tide

Code ⬆

NDC Code