eflornithine (systemic)

Contraindicated in:

OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Severe renal impairment (↓ dose);
Rep: Women of reproductive potential and men with female partners of reproductive potential.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: alopecia, rash, skin infection

EENT: conjunctivitis, otitis media, sinusitis, hearing loss

Endo: hyperglycemia, hypoglycemia

F and E: hyperkalemia, hypokalemia, hyponatremia

GI: diarrhea, vomiting, ↑liver enzymes, HEPATOTOXICITY

GU: urinary tract infection

Hemat: anemia, leukopenia, NEUTROPENIA, THROMBOCYTOPENIA

MS: pain

Resp: allergic rhinitis, cough, pneumonia

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

PO (Adults and Children body surface area (BSA) >1.5 m²): 768 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.
PO (Adults and Children BSA 0.75–1.5 m²): 576 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.
PO (Adults and Children BSA 0.5–<0.75 m²): 384 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.
PO (Adults and Children BSA 0.25–<0.5 m²): 192 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.

Renal Impairment

PO (Adults and Children BSA >1.5 m²): CCr <30 mL/min: 384 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.

Renal Impairment

PO (Adults and Children BSA 0.75–1.5 m²): CCr <30 mL/min: 384 mg in the morning and 192 mg in the evening for 2 yr or until disease recurrence or unacceptable toxicity.

Renal Impairment

PO (Adults and Children BSA 0.5–<0.75 m²): CCr <30 mL/min: 192 mg twice daily for 2 yr or until disease recurrence or unacceptable toxicity.

Renal Impairment

PO (Adults and Children BSA 0.25–<0.5 m²): CCr <30 mL/min: 192 mg once daily for 2 yr or until disease recurrence or unacceptable toxicity.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits ornithine decarboxylase, which is the rate-limiting enzyme in the biosynthesis of polyamines. Polyamines are necessary for cell growth and differentiation because they are required for the synthesis of DNA, RNA, and proteins. Additionally, inhibition of ornithine decarboxylase reverses the effects of the LIN28/Let7 metabolic pathway, which reduces expression of certain proteins (involved in cancer stem cell regulation and glycolytic metabolism), decreasing expression of the oncogenic drivers MYCN and LIN28B.

Therapeutic effects:

Reduction in disease progression, relapse, secondary cancer, or death.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: temporary class

Pharmacokinetics ⬆ ⬇

Absorption: Extent of absorption following oral administration unknown.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Unknown.

Half-Life: 3.5 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	3.5 hr	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise to take as directed. If a dose is missed and it is <7 hr until next dose, skip dose, and take at normal time. Do not take two doses at the same time or extra doses.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Advise patient to notify a health care professional if signs and symptoms of hepatotoxicity and/or myelosuppression occur.
Rep: May cause fetal harm. Advise women of reproductive potential to use effective contraception during therapy and for 1 wk after last dose. Advise women not to breastfeed during therapy and for 1 wk after last dose.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

51767- CoreRx, Inc.
- 51767-150-
  - 51767-150-01- 17000 TABLET in 1 DRUM (51767-150-01)

54245- SciAnda (Changshu) Pharmaceuticals, Ltd.
- 54245-3110-
  - 54245-3110-0- 70 kg in 1 BAG (54245-3110-0)

65129- ScinoPharm Taiwan Ltd.
- 65129-3110-
  - 65129-3110-0- 60 kg in 1 BAG (65129-3110-0)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-01- 50 g in 1 JAR (73377-257-01)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-02- 500 g in 1 JAR (73377-257-02)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-03- 1000 g in 1 JAR (73377-257-03)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-04- 980 g in 1 JAR (73377-257-04)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-05- 100 g in 1 JAR (73377-257-05)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-06- 993 g in 1 JAR (73377-257-06)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-07- 25 g in 1 JAR (73377-257-07)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-08- 49 g in 1 JAR (73377-257-08)

73377- AX Pharmaceutical Corp
- 73377-257-
  73377-257-09- 960 g in 1 JAR (73377-257-09)

78670- USWM, LLC
- 78670-150- iwilfin
  78670-150-01- 1 BOTTLE in 1 CARTON (78670-150-01) / 100 TABLET in 1 BOTTLE

82160- Pella Pharmaceuticals Co. Ltd
- 82160-125- Florexa
  - 82160-125-01- 1 TUBE in 1 CARTON (82160-125-01) / 30 g in 1 TUBE

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

Code ⬆