dornase alfa

Contraindicated in:

Hypersensitivity to dornase alfa or Chinese Hamster Ovary cell products.

Use Cautiously in:

Pedi: ↑incidence of cough, rhinitis, and rash in children;
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding.

Adv. Reactions/Side Effects ⬆ ⬇

CV: chest pain

Derm: rash

EENT: rhinitis, sore throat, voice alteration, conjunctivitis, hoarseness

Resp: cough, dyspnea

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Solution for inhalation: 1 mg/mL

Route/Dosage ⬆ ⬇

Inhaln (Adults and Children ): 2.5 mg once or twice daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Breaks down excessive amounts of DNA found in the respiratory tract of patients with cystic fibrosis. Excessive DNA contributes to increased sputum viscosity and risk of infection.

Therapeutic effects:

Decreased infection rates and requirement for parenteral anti-infectives.
Improved pulmonary function.

Classifications ⬆ ⬇

Therapeutic Classification: cystic fibrosis therapy adjuncts

Pharmacologic Classification: pulmonary enzymes

Pharmacokinetics ⬆ ⬇

Absorption: Negligible absorption following inhalation.

Distribution: Action is primarily local.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(effect on noted parameters)

ROUTE	ONSET	PEAK	DURATION
Inhalation	within 15 min‡	3 days–1 wk‡ weeks–months§	48 hr

‡Significant concentrations in sputum.

‡Improvement in respiratory function.

§Decreased incidence of respiratory tract infections.

Patient/Family Teaching ⬆ ⬇

Instruct patient to take dornase alfa exactly as directed, at the same time each day. If a dose is missed, take as soon as possible; if almost time for next dose, skip missed dose and return to regular dosing schedule.
- Emphasize the importance of continuing other medications for cystic fibrosis during dornase alfa therapy.
- Instruct patient in proper technique for dornase alfa administration. Wash hands before assembling nebulizer and adding medication. Use a clean surface to assemble nebulizer, and keep nebulizer parts clean according to manufacturer’s directions. Open ampule and empty into nebulizer cup; use all of medication in ampule. Administer according to manufacturer’s directions. Clean nebulizer following use.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

50242- Genentech, Inc.
- 50242-099-
  - 50242-099-01- 120 L in 1 TANK (50242-099-01)

50242- Genentech, Inc.
- 50242-099-
  - 50242-099-02- 300 L in 1 TANK (50242-099-02)

50242- Genentech, Inc.
- 50242-100- Pulmozyme
  - 50242-100-40- 5 POUCH in 1 CARTON (50242-100-40) / 6 AMPULE in 1 POUCH (50242-100-39) / 2.5 mL in 1 AMPULE

69438- Lonza Biologics Tuas Pte Ltd.
- 69438-0012-
  - 69438-0012-1- 300000 mL in 1 DEWAR (69438-0012-1)

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇