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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: eye irritation/burning/stinging/itching, nasopharyngitis

Neuro: headache

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Lastacaft

Action ⬆ ⬇

  • Antagonizes the effects of histamine at H1 receptor sites in the eye; does not bind or inactivate histamine.
  • Also decreases histamine release from mast cells.
Therapeutic effects:
  • Decreased symptoms of histamine excess including itching, redness, tearing.

Classifications ⬆ ⬇

Therapeutic Classification: ocular agents

Pharmacologic Classification: antihistamines

Pharmacokinetics ⬆ ⬇

Absorption: Minimal systemic absorption follows ophthalmic use.

Distribution: Unknown.

Metabolism/Excretion: Some conversion to an active carboxylic acid metabolite, which is excreted unchanged by the kidneys.

Half-Life: 2 hr (carboxylic acid metabolite).

Time/Action Profile ⬆ ⬇

(antihistaminic effect)

ROUTEONSETPEAKDURATION
ophth3 minunknown16 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

al-KAFF-ta-deen

Code ⬆

NDC Code