arimoclomol

Contraindicated in:

OB: Pregnancy.

Use Cautiously in:

eGFR 15–<50 mL/min (adjust dosage frequency);
End-stage renal disease;
Rep: Women of reproductive potential;
Lactation: Safety not established in breastfeeding;
Pedi: Children <2 yr (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

Derm: urticaria

GI: diarrhea

GU: ↓fertility, ↑serum creatinine

Hemat: thrombocytopenia

Metab: ↓appetite, weight loss

Neuro: headache, seizure, tremor

Resp: respiratory tract infection

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

May ↑ levels and risk of toxicity of organic cationic transporter 2 (OCT2) substrates; ↓ dose of OCT2 substrate.

Availability ⬆ ⬇

Capsules: 47 mg; 62 mg; 93 mg; 124 mg

Route/Dosage ⬆ ⬇

PO (Adults and Children ≥2 yr and >55 kg): 124 mg three times daily.
PO (Adults and Children ≥2 yr and >30–55 kg): 93 mg three times daily.
PO (Adults and Children ≥2 yr and >15–30 kg): 62 mg three times daily.
PO (Adults and Children ≥2 yr and 8–15 kg): 47 mg three times daily.

Renal Impairment

PO (Adults and Children ≥2 yr and >55 kg): CCr 15–<50 mL/min: 124 mg twice daily.

Renal Impairment

PO (Adults and Children ≥2 yr and >30–55 kg): CCr 15–<50 mL/min: 93 mg twice daily.

Renal Impairment

PO (Adults and Children ≥2 yr and >15–30 kg): CCr 15–<50 mL/min: 62 mg twice daily.

Renal Impairment

PO (Adults and Children ≥2 yr and 8–15 kg): CCr 15–<50 mL/min: 47 mg twice daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Mechanism by which arimoclomol exerts its therapeutic effects is unknown.

Therapeutic effects:

Improvement in ambulation, speech, swallowing, and fine motor skills.

Classifications ⬆ ⬇

Therapeutic Classification: none assigned

Pharmacokinetics ⬆ ⬇

Absorption: Extent of absorption following oral administration unknown.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Primarily metabolized in the liver via glutathionation and O-glucuronidation. 12% excreted in feces; 78% excreted in urine (42% as unchanged drug).

Half-Life: 4 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	0.5 hr	12 hr

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy. If a dose is missed, skip the dose, and resume dosing at next scheduled time.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Advise patient to notify health care professional of signs/symptoms of hypersensitivity reactions and seek immediate medical attention if needed.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Advise patient to use effective contraception during treatment. May impair fertility.

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆