Toxoplasmosis (in Patients without HIV)
- PO (Adults ): 50–200 mg once daily for 1–2 days, followed by 25–50 mg once daily for 2–6 wk.
- PO (Children ): 1 mg/kg once daily for 1–3 days, then 0.5 mg/kg once daily for 4–6 wk.
Toxoplasmosis (in Patients with HIV)
- PO (Adults ): 100–200 mg once daily for 1–2 days, followed by 50–100 mg once daily for 3–6 wk, then 25–50 mg once daily for life.
Therapeutic Classification: antiprotozoals
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed with high concentrations achieved in blood cells, kidneys, lungs, liver, and spleen. Some enters CSF (13–26% of serum levels).
Metabolism/Excretion: Mostly metabolized by the liver. 20–30% excreted unchanged by the kidneys.
Half-Life: 4 days (↓ in patients with HIV).
