elagolix/estradiol/norethindrone

Contraindicated in:

Hypersensitivity to elagolix, estradiol, or norethindrone;
History of cigarette smoking and age >35 yr (↑ risk of cardiovascular or thromboembolic phenomenon)
;
Thromboembolic disease (e.g., deep vein thrombosis [DVT], pulmonary embolism [PE], MI, stroke)
;
Uncontrolled hypertension
;
Cerebrovascular disease, coronary artery disease, or peripheral vascular disease;
Valvular heart disease or thrombogenic heart rhythms;
Protein C, protein S, or antithrombin deficiency or other thrombophilic disorder;
Headache with focal neurological symptoms or migraine headaches with aura in women >35 yr;
Major surgery with extended periods of immobility;
Osteoporosis (may ↑ risk of bone loss);
Breast cancer or other hormone-sensitive malignancy;
↑risk for hormone sensitive malignancy;
Hepatic impairment;
Undiagnosed abnormal uterine bleeding;
Concurrent use of strong organic anion transporting polypeptide (OATP) 1B1 inhibitors;
OB: Pregnancy.

Use Cautiously in:

Aspirin hypersensitivity (contains tartrazine, which may cause allergic reaction);
History of low-trauma fracture or other risk factors for osteoporosis;
History of suicidal thoughts/behaviors or depression;
Controlled hypertension;
Diabetes;
Hypertriglyceridemia (↑ risk of pancreatitis);
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Rep: Women of reproductive potential;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: ↑BP, alopecia, DVT, MI

Endo: hot flush, hyperglycemia

GI: ↑liver enzymes, cholelithiasis, vomiting

GU: ↓libido, metrorrhagia

Metab: hyperlipidemia, weight gain

MS: ↓bone density, arthralgia

Neuro: depression, headache, mood swings, STROKE, SUICIDAL THOUGHTS/BEHAVIOR

Resp: PE

Misc: fatigue, MALIGNANCY (BREAST, ENDOMETRIAL, OVARIAN)

Interactions ⬆ ⬇

Drug-drug:

Strong OATP1B1 inhibitors, including rifampin, may significantly ↑ elagolix levels and risk of toxicity; concurrent use contraindicated.
Corticosteroids, anticonvulsants, and proton pump inhibitors may ↑ risk for bone loss.
Elagolix may ↓ levels and effectiveness of CYP3A substrates, including midazolam; consider ↑ midazolam dose.
Elagolix may ↑ levels and risk of toxicity of CYP2C19 substrates, including omeprazole; consider ↓ omeprazole dose when using higher doses (>40 mg/day).
Elagolix may ↑ levels and risk of toxicity of P-glycoprotein substrates, including digoxin; closely monitor digoxin levels.
May ↓ rosuvastatin levels and effectiveness; consider ↑ rosuvastatin dose.
Strong CYP3A inhibitors may ↑ elagolix, estradiol, and norethindrone levels and risk of toxicity; concurrent use not recommended.
Strong CYP3A inducers may ↓ elagolix, estradiol, and norethindrone levels and effectiveness.

Availability ⬆ ⬇

Capsules: elagolix 300 mg/estradiol 1 mg/norethindrone 0.5 mg (morning capsule); elagolix 300 mg (evening capsule)

Route/Dosage ⬆ ⬇

PO (Adults ): One morning capsule (elagolix 300 mg/estradiol 1 mg/norethindrone 0.5 mg) every morning and one evening capsule (elagolix 300 mg) every evening. Continue for no longer than 24 mo.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Elagolix: Competitively binds to and inhibits gonadotropin-releasing hormone receptors in the pituitary gland, causing a decrease in the release of estradiol and progesterone by the ovaries, reducing bleeding associated with uterine fibroids. Estradiol: Binds to estrogen receptors and reduces the increase in bone resorption and potential bone loss associated with elagolix. Norethindrone: Protects uterus from potential adverse endometrial effects caused by unopposed estrogen use.

Therapeutic effects:

Reduced menstrual blood loss.

Classifications ⬆ ⬇

Therapeutic Classification: hemostatic agents, hormones

Pharmacologic Classification: gnrh antagonist, estrogens, progestins

Pharmacokinetics ⬆ ⬇

Elagolix

Absorption: Rapidly absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A isoenzyme with some metabolism by the CYP2D6 and CYP2C8 isoenzymes as well as UGT. 90% of dose excreted in feces; <3% in urine.

Half-Life: 4–6 hr.

Estradiol

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed.

Protein Binding: 98%.

Metabolism/Excretion: Metabolized by the liver via the CYP3A isoenzyme; also undergoes sulfation and glucuronidation. Enterohepatic recirculation occurs; more absorption may occur from the GI tract.

Half-Life: 8–20 hr.

Norethindrone

Absorption: Rapidly absorbed following oral administration.

Distribution: Unknown.

Protein Binding: 97%.

Metabolism/Excretion: Metabolized by the liver via the CYP3A isoenzyme.

Half-Life: 5–13 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	rapid	1–2 hr	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
Instruct patient to take missed doses within 4 hr of original time; then take next scheduled dose. If missed dose is >4 hr of original time, omit and take next scheduled dose.
Advise patient to stop taking medication and notify health care provider immediately if signs and symptoms of cardiovascular conditions (leg pain or swelling that will not go away; sudden shortness of breath; double vision; bulging of the eyes; sudden blindness, partial or complete; pain or pressure in chest, arm, or jaw; sudden, severe headache unlike usual headaches; weakness or numbness in an arm or leg; trouble speaking) occur.
Inform patient of risk of bone loss. Advise patient to take supplementary calcium and vitamin D and to avoid taking iron supplements at same time.
Instruct patient to pay attention to changes in mood, behaviors, thoughts, or feelings. Advise patients to notify health care provider immediately if signs and symptoms of suicidal ideation and behavior changes (thoughts about suicide or dying, suicide attempts, new or worse depression, new or worse anxiety) occur.
Advise patient to notify health care provider if signs and symptoms of liver injury (jaundice, dark amber-colored urine, feeling tired, nausea and vomiting, generalized swelling, right upper stomach area pain, bruising easily) occur.
Advise patient that alopecia and hair thinning in no specific pattern may occur and may not completely resolve after discontinuing therapy. Advise patient to consult health care provider with concerns about changes to hair.
Caution patient that cigarette smoking during estrogen therapy may ↑ risk of serious side effects, especially for women over age 35.
Instruct patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to avoid concurrent use of Rx, OTC, and herbal products without consulting health care provider.
Dispose unused medication via a take-back option if available. Otherwise, follow FDA instructions for disposing medication in the household trash: www.fda.gov/drugdisposal. Do NOT flush down the toilet.
Rep: Inform patient that therapy may ↓ menstrual bleeding or result in no bleeding, making it hard to detect pregnancy; watch for other signs of pregnancy (breast tenderness, weight gain, nausea). May result in pregnancy loss if used in early pregnancy. Advise women of reproductive potential to use effective nonhormonal contraception during therapy and for 1 wk after last dose. Hormonal contraceptives may ↓ effectiveness of elagolix and ↑ risk of thromboembolic and vascular events. Advise patient to notify health care provider if pregnancy is planned or suspected or if breastfeeding. Encourage patients who become pregnant during therapy to enroll in pregnancy exposure registry: 1-833-782-7241;https://www.bloompregnancyregistry.com.

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Indications ⬇

Contraind./Precautions ⬆ ⬇