Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children
;CV: hypotension, arrhythmias
Derm: photosensitivity, rash
EENT: blurred vision, ↑intraocular pressure
GI: constipation, dry mouth, hepatitis, nausea, paralytic ileus
GU: ↓libido, urinary retention
Hemat: blood dyscrasias
Neuro: fatigue, sedation, agitation, confusion, hallucinations, SUICIDAL THOUGHTS/BEHAVIORS
Misc: hypersensitivity reactions
Drug-drug:
Drug-Natural Products:
Therapeutic Classification: antianxiety agents, antidepressants, sedative/hypnotics
Pharmacologic Classification: tricyclic antidepressants
Absorption: Well absorbed from the GI tract, although much is metabolized on first pass through the liver.
Distribution: Widely distributed to tissues.
Half-Life: 8–25 hr.
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior.
NDC Code