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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, alopecia

GI: abdominal pain, constipation

Hemat: anemia

Neuro: mood swings

Misc: copper deficiency, hypersensitivity reactions, iron deficiency, systemic lupus erythematosus

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

Cuvrior

Syprine

US Brand Names ⬆ ⬇

Cuvrior, Syprine

Action ⬆ ⬇

  • Forms a complex with absorbed copper, which is then eliminated from the body through the urine. Also binds to copper in the GI tract, reducing its absorption.
Therapeutic effects:
  • Reduction of copper concentrations in the bloodstream.

Classifications ⬆ ⬇

Therapeutic Classification: antidotes

Pharmacologic Classification: chelating agents

Pharmacokinetics ⬆ ⬇

Absorption: Poorly absorbed from GI tract.

Distribution: Unknown.

Metabolism/Excretion: Acetylated into two major active metabolites. Trientine and active metabolites are excreted into urine.

Half-Life: 13.8–16.5 hr

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown1.25–2 hrunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

TRYE-en-teen

Code ⬆

NDC Code