Instruct patient to report unusual bleeding or bruising. Advise patient of thrombocytopenia precautions (use soft toothbrush, electric razor, and avoid falls; do not drink alcoholic beverages or take medication containing aspirin or NSAIDs because they may precipitate GI bleeding).

Caution patient to avoid crowds and persons with known infections. Health care provider should be informed immediately if symptoms of infection (fever, sore throat, chills, cough, hoarseness, lower back or side pain, difficult or painful urination) or rash occurs.

May cause fetal harm. Advise patient to use reliable form of contraception during therapy. Instruct patient to inform health care provider if pregnancy is planned or suspected and to avoid breastfeeding during therapy. May ↓ fertility.