High Alert
Contraindicated in:
Use Cautiously in:
Derm: alopecia
EENT: ototoxicity tinnitus
F and E: hypocalcemia, hypokalemia, hypomagnesemia
GI: nausea vomiting
GU:
nephrotoxicity
, sterilityHemat: anemia
Local: phlebitis at IV site
Neuro: malaise, peripheral neuropathy, REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME (RPLS), SEIZURES, weakness
Misc: ANAPHYLAXIS
Drug-drug:
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed; accumulates for months.
Half-Life: 30–100 hr.
Instruct patient to report difficulty with hearing or tinnitus immediately.
Instruct patient to notify health care provider promptly if fever; chills; cough; hoarseness; sore throat; signs of infection; lower back or side pain; painful or difficult urination; bleeding gums; bruising; petechiae; blood in stools, urine, or emesis; ↑ fatigue; dyspnea; or orthostatic hypotension occurs. Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor and to avoid falls. Caution patient not to drink alcoholic beverages or take medication containing aspirin or NSAIDs; may precipitate gastric bleeding.
NDC Code
