(Adults and Children ≥9 yr): Apply once daily in the evening.
US Brand Names⬆⬇
Aklief
Action⬆⬇
Stimulates retinoic acid receptors, resulting in anti-inflammatory effects.
Therapeutic effects:
Decreased severity of acne vulgaris.
Classifications⬆⬇
Therapeutic Classification: antiacne agents
Pharmacologic Classification: retinoids
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption.
Distribution: Unknown.
Protein Binding: >99%.
Metabolism/Excretion: Primarily metabolized by CYP2C8, CYP2C9, and CYP3A4. Primarily excreted in feces.
Half-Life: 2–9 hr.
Time/Action Profile⬆⬇
(improvement in lesions)
ROUTE
ONSET
PEAK
DURATION
Topical
within 12 wks
Unknown
Unknown
Patient/Family Teaching⬆⬇
Instruct patient on application technique. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Inform patient that erythema, scaling, dryness, and stinging/burning may occur, with greatest severity within the first 4 weeks of therapy. Severity usually decreases with continued use of trifarotene. Instruct patient to use a moisturizer, reduce the frequency of application, or suspend use temporarily. If severe reactions persist therapy may be discontinued.
Advise patient to avoid application to cuts, abrasions, or eczematous or sunburned skin and to avoid use of “waxing” as a depilatory method in the area treated.
Caution patient to minimize unprotected exposure to ultraviolet rays (including sunlight and sunlamps) during therapy. Warn patients who normally experience high levels of sun exposure and those with inherent sensitivity to sun to exercise caution. Use sunscreen products and protective clothing over treated areas when exposure cannot be avoided.
Advise patient to avoid concomitant use of other potentially irritating topical products (medicated or not).
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding. If breastfeeding, use cream on the smallest area of skin and for the shortest duration possible to minimize potential exposure to the breastfed infant via breast milk. Advise breastfeeding women not to apply cream directly to nipple and areola to avoid direct infant exposure.
Pronunciation⬆⬇
trye-FAR-oh-teen
Code⬆
NDC Code
0299- Galderma Laboratories, L.P.
0299-5935- AKLIEF
0299-5935-02- 1 TUBE in 1 BLISTER PACK (0299-5935-02) / 2 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-5935- AKLIEF
0299-5935-45- 1 BOTTLE, PUMP in 1 CARTON (0299-5935-45) / 45 g in 1 BOTTLE, PUMP
17337- Olon S.p.A.
17337-0432-
17337-0432-0- 1 BAG in 1 DRUM (17337-0432-0) / 1 BOTTLE, GLASS in 1 BAG / .5 kg in 1 BOTTLE, GLASS
