flurandrenolide

Contraindicated in:

Hypersensitivity or known intolerance to corticosteroids or components of vehicles (ointment or base, preservative, alcohol);
Untreated bacterial or viral infections.

Use Cautiously in:

Hepatic impairment;
Diabetes mellitus, cataracts, glaucoma, or tuberculosis (use of large amounts of high-potency agents may worsen condition);
Patients with pre-existing skin atrophy;
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk (chronic high-dose usage may result in adrenal suppression in mother, growth suppression in children);
Pedi: Chronic high-dose usage may result in adrenal and growth suppression in children.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: allergic contact dermatitis, atrophy, burning, dryness, edema, folliculitis, hypertrichosis, hypopigmentation, irritation, maceration, miliaria, perioral dermatitis, secondary infection, striae

Misc: adrenal suppression (use of occlusive dressings, long-term therapy), hypersensitivity reactions

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

(Generic available)

Cream: 0.05%
Lotion: 0.05%
Ointment: 0.05%
Tape: 4 mcg/cm²

Route/Dosage ⬆ ⬇

(Adults ): Apply to affected area(s) 2–3 times daily (depends on product, preparation, and condition being treated).
(Children ): Apply to affected area(s) 1–2 times daily (depends on product, preparation, and condition being treated).

US Brand Names ⬆ ⬇

Cordran, ~~Cordran SP~~

Action ⬆ ⬇

Suppresses normal immune response and inflammation.

Therapeutic effects:

Suppression of dermatologic inflammation and immune processes.

Classifications ⬆ ⬇

Therapeutic Classification: corticosteroids

Pharmacologic Classification: corticosteroids

Pharmacokinetics ⬆ ⬇

Absorption: Minimal. Prolonged use on large surface areas or large amounts applied or use of occlusive dressings may increase systemic absorption.

Distribution: Remains primarily at site of action.

Metabolism/Excretion: Usually metabolized in skin.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(response depends on condition being treated)

ROUTE	ONSET	PEAK	DURATION
Topical	min–hrs	hrs–days	hrs–days

Patient/Family Teaching ⬆ ⬇

Instruct patient on correct technique of medication administration. Emphasize importance of avoiding the eyes. If a dose is missed, it should be applied as soon as remembered unless almost time for the next dose.
Caution patient to use only as directed. Avoid using cosmetics, bandages, dressings, or other skin products over the treated area unless directed by health care professional.
Advise parents of pediatric patients not to apply tight-fitting diapers or plastic pants on a child treated in the diaper area; these garments work like an occlusive dressing and may cause more of the drug to be absorbed.
Advise patient to consult health care professional before using medicine for condition other than indicated.
Rep: May cause fetal harm. Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Caution women that medication should not be used extensively, in large amounts, or for protracted periods in patients who are pregnant or planning to become pregnant.
Instruct patient to inform health care professional if symptoms of underlying disease return or worsen or if symptoms of infection develop.

Pronunciation ⬆ ⬇

floor-an-DREN-oh-lide

Code ⬆

NDC Code

16110- Almirall, LLC
- 16110-587- CORDRAN
  - 16110-587-24- 1 BOTTLE in 1 CARTON (16110-587-24) / 450 cm2 in 1 BOTTLE

16110- Almirall, LLC
- 16110-587- CORDRAN
  - 16110-587-80- 1 BOTTLE in 1 CARTON (16110-587-80) / 1500 cm2 in 1 BOTTLE

17518- Solventum US LLC
- 17518-587-
  - 17518-587-24- 450 cm2 in 1 CARTON (17518-587-24)

45802- Padagis Israel Pharmaceuticals Ltd
- 45802-928- Flurandrenolide
  - 45802-928-03- 120 mL in 1 BOTTLE, PLASTIC (45802-928-03)

46439- Farmabios S.p.A.
- 46439-8723-
  - 46439-8723-1- 4000 g in 1 DRUM (46439-8723-1)

63629- Bryant Ranch Prepack
- 63629-8657- Flurandrenolide
  - 63629-8657-1- 1 BOTTLE, PLASTIC in 1 CARTON (63629-8657-1) / 120 mL in 1 BOTTLE, PLASTIC

72162- Bryant Ranch Prepack
- 72162-1439- Flurandrenolide
  - 72162-1439-2- 120 mL in 1 BOTTLE (72162-1439-2)

74157- INA Pharmaceutics, Inc
- 74157-130- CORDRAN
  - 74157-130-07- 1 TUBE in 1 CARTON (74157-130-07) / 120 g in 1 TUBE

74157- INA Pharmaceutics, Inc
- 74157-180- CORDRAN
  - 74157-180-60- 1 TUBE in 1 CARTON (74157-180-60) / 60 g in 1 TUBE

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Indications ⬇

Contraind./Precautions ⬆ ⬇