Acute Bleeding Syndromes due to Elevated Fibrinolytic Activity
- PO (Adults ): 5 g during the 1st hr, followed by 1–1.25 g every hr for 8 hr or until hemorrhage is controlled; or 6 g over 24 hr after prostate surgery (not to exceed 30 g/day).
- IV (Adults ): 4–5 g over 1st hr, followed by 1 g/hr for 8 hr or until hemorrhage is controlled; or 6 g over 24 hr after prostate surgery (not to exceed 30 g/day).
- PO IV (Children ): 100 mg/kg or 3 g/m2 over 1st hr, followed by continuous infusion of 33.3 mg/kg/hr; or 1 g/m2/hr (total dose not to exceed 18 g/m2/24 hr).
Subarachnoid Hemorrhage
- PO (Adults ): To follow IV: 3 g every 2 hr (36 g/day). If no surgery is performed, continue for 21 days after bleeding stops; then ↓ to 2 g every 2 hr (24 g/day) for 3 days; then 1 g every 2 hr (12 g/day) for 3 days.
- IV (Adults ): 36 g/day for 10 days followed by PO.
Prevention of Bleeding Following Oral Surgery in Hemophiliacs
- PO (Adults ): 75 mg/kg (up to 6 g) immediately after procedure; then every 6 hr for 7–10 days; syrup may also be used as an oral rinse of 1.25 g (5 mL) 4 times a day for 7–10 days.
- IV PO (Children ): Also for epistaxis: 50–100 mg/kg/dose administered IV every 6 hr for 2–3 days starting 4 hr before the procedure. After completion of IV therapy, aminocaproic acid should be given as 50–100 mg/kg/dose orally every 6 hr for 5–7 days.