Interactions are listed for systemically absorbed drug
Drug-drug:
Preoperative Intestinal Antisepsis
- PO (Adults ): 1 g every hr for 4 doses, then 1 g every 4 hr for 5 doses or 1 g at 1 PM, 2 PM, and 11 PM on day before surgery.
- PO (Children ): 15 mg/kg every 4 hr for 2 days or 25 mg/kg at 1 PM, 2 PM, and 11 PM on day before surgery.
Hepatic Encephalopathy
- PO (Adults ): 1–3 g every 6 hr for 5–6 days; may be followed by 4 g/day chronically.
- PO (Children ): 12.5–25 mg/kg every 6 hr for 5–6 days (max dose 12 g/day).
Therapeutic Classification: anti-infectives
Pharmacologic Classification: aminoglycosides
Absorption: Minimal systemic absorption, but may accumulate in patients with renal failure.
Distribution: Widely distributed throughout extracellular fluid; crosses the placenta; small amounts enter breast milk. Poor penetration into CSF.
Metabolism/Excretion: Excretion is >90% renal.
Half-Life: 2–4 hr (increased in renal impairment).
