dichlorphenamide

Contraindicated in:

Hypersensitivity or cross-sensitivity with sulfonamides;
Hepatic insufficiency;
Severe pulmonary obstruction;
Concurrent use of high-dose aspirin.

Use Cautiously in:

Concurrent use of low-dose aspirin;
Adrenocortical excess or renal tubular acidosis (↑ risk of hypokalemia);
OB: Use during pregnancy only if potential maternal benefit justifies fetal risks;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children;
Geri: ↑risk of falls and metabolic acidosis in older adults.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: pruritus, rash, STEVENS-JOHNSON SYNDROME

EENT: pharyngolaryngeal pain

F and E: hyperchloremic non-anion gap metabolic acidosis, hypokalemia

GI: diarrhea, nausea

Hemat: APLASTIC ANEMIA, HEMOLYTIC ANEMIA, LEUKOPENIA

Metab: ↓weight

MS: arthralgia, muscle spasms/twitching

Neuro: confusion, drowsiness, dysgeusia, paresthesias, fatigue

Resp: dyspnea

Misc: ↑falls risk, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

↑aspirin levels/toxicity; concurrent use with high-dose aspirin may result in anorexia, lethargy, and coma and is contraindicated..
Concurrent use with antifungals, laxatives, loop diuretics, penicillin, thiazide diuretics andtheophylline may ↑ risk of hypokalemia.
Concurrent use with other drugs that cause hyperchloremic metabolic acidosis may ↑ risk and severity of metabolic acidosis.
Excretion of barbiturates, aspirin, and lithium is ↑ and may lead to ↓ effectiveness.
Excretion of amphetamine,quinidine, procainamide, and possibly tricyclic antidepressants is ↓ and may lead to toxicity.

Availability ⬆ ⬇

(Generic available)

Tablets: 50 mg

Route/Dosage ⬆ ⬇

PO (Adults ): 50 mg once or twice daily; titrate according to response, not to exceed 200 mg/day.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits renal carbonic anhydrase, resulting in self-limiting urinary excretion of sodium, potassium, bicarbonate, and water.

Therapeutic effects:

Reduced incidence/severity of muscle weakness associated with periodic paralysis.

Classifications ⬆ ⬇

Therapeutic Classification: diuretics

Pharmacologic Classification: carbonic anhydrase inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Crosses the placenta.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient to take dichlorphenamide as directed.
Caution patient to discontinue therapy and notify health care professional is rash or signs and symptoms of allergic reaction occur.
Advise patient to report worsening symptoms of periodic paralysis to health care professional.
May occasionally cause drowsiness. Caution patient to avoid driving and other activities that require alertness until response to the drug is known.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications, especially aspirin.
Rep: May cause fetal harm. Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Monitor newborns of mothers treated with dichlorphenamide for metabolic acidosis.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

13668- Torrent pharmaceuticals limited
- 13668-676- Dichlorphenamide
  - 13668-676-01- 100 TABLET in 1 BOTTLE (13668-676-01)

13668- Torrent pharmaceuticals limited
- 13668-676- Dichlorphenamide
  - 13668-676-30- 30 TABLET in 1 BOTTLE (13668-676-30)

58159- NURAY CHEMICALS PRIVATE LIMITED
- 58159-071-
  - 58159-071-01- 35 kg in 1 DRUM (58159-071-01)

58159- NURAY CHEMICALS PRIVATE LIMITED
- 58159-071-
  - 58159-071-02- 20 kg in 1 DRUM (58159-071-02)

58159- NURAY CHEMICALS PRIVATE LIMITED
- 58159-071-
  - 58159-071-03- 15 kg in 1 DRUM (58159-071-03)

58159- NURAY CHEMICALS PRIVATE LIMITED
- 58159-071-
  58159-071-04- 10 kg in 1 DRUM (58159-071-04)

58159- NURAY CHEMICALS PRIVATE LIMITED
- 58159-071-
  58159-071-05- 5 kg in 1 DRUM (58159-071-05)

59651- Aurobindo Pharma Limited
- 59651-223-
  59651-223-37- 50 kg in 1 DRUM (59651-223-37)

70709- Cycle Pharmaceuticals Ltd.
- 70709-085- ORMALVI
  70709-085-10- 100 TABLET in 1 BOTTLE (70709-085-10)

71090- Strongbridge US Inc.
- 71090-001- Keveyis
  - 71090-001-01- 100 TABLET in 1 BOTTLE (71090-001-01)

72065- Xeris Pharmaceuticals, Inc.
- 72065-001- Keveyis
  - 72065-001-01- 100 TABLET in 1 BOTTLE (72065-001-01)

73435- Biophore India Pharmaceuticals Pvt. Ltd
- 73435-011-
  - 73435-011-11- 15 kg in 1 DRUM (73435-011-11)

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Indications ⬇

Contraind./Precautions ⬆ ⬇