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Indications ⬇

BEERS REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: first-dose orthostatic hypotension, palpitations, angina, edema, syncope

EENT: blurred vision, intraoperative floppy iris syndrome

GI: abdominal cramps, diarrhea, dry mouth, nausea, vomiting

GU: erectile dysfunction, priapism

Neuro: dizziness, headache, weakness, depression, drowsiness

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hypertension

Benign Prostatic Hyperplasia

US Brand Names ⬆ ⬇

Minipress

Action ⬆ ⬇

  • Dilates both arteries and veins by blocking postsynaptic alpha1-adrenergic receptors.
  • Decreases contractions in smooth muscle of prostatic capsule.
Therapeutic effects:
  • Lowering of BP.
  • Decreased symptoms of prostatic hyperplasia (urinary urgency, urinary hesitancy, nocturia).

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives

Pharmacologic Classification: peripherally acting antiadrenergics

Pharmacokinetics ⬆ ⬇

Absorption: 60% absorbed following oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 97%.

Metabolism/Excretion: Extensively metabolized by the liver. Minimal (5–10%) renal excretion of unchanged drug.

Half-Life: 2–3 hr.

Time/Action Profile ⬆ ⬇

(antihypertensive effects)

ROUTEONSETPEAKDURATION
PO2 hr2–4 hr‡10 hr

‡Following single dose; maximal antihypertensive effects occur after 3–4 wk of chronic dosing.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

PRA-zoe-sin

Code ⬆

NDC Code