Do not use concurrently with insect repellent products containing N,N-diethyl-m-toluamide (DEET). Alitretinoin increases DEET absorption.
Availability⬆⬇
Topical gel: 0.1% in 60-g tubes
Route/Dosage⬆⬇
(Adults ): Apply generous coating twice daily to KS lesions initially; application may be increased to 3–4 times daily.
US Brand Names⬆⬇
Panretin
Action⬆⬇
Binds to and activates retinoid receptors, resulting in inhibition of KS cells.
Therapeutic effects:
Decreased cutaneous lesions of KS.
Classifications⬆⬇
Therapeutic Classification: antineoplastics
Pharmacologic Classification: retinoids
Pharmacokinetics⬆⬇
Absorption: Small amounts are absorbed.
Distribution: Unknown.
Metabolism/Excretion: Some metabolism occurs.
Half-Life: Unknown.
Time/Action Profile⬆⬇
(response of KS lesions)
ROUTE
ONSET
PEAK
DURATION
topical
2 wk
4–14 wk
unknown
Patient/Family Teaching⬆⬇
Instruct patient in correct method for application of gel. Emphasize the importance of continuing treatment, even if results are not visible. Prolonged therapy may be required.
Advise patient to notify health care professional if signs of dermal toxicity occur.
Caution patient to minimize exposure of treated areas to sunlight or sunlamps to prevent photosensitivity reactions.
Advise patient to avoid use of products, such as insect repellents, which contain DEET during treatment. Alitretinoin may increase DEET toxicity.
