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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, DEEP VEIN THROMBOSIS

Derm: acne, hirsutism, oiliness

EENT: deepening of voice

Endo: ↓breast size (women), amenorrhea, anovulation, ↓libido

GI: hepatitis (cholestatic jaundice)

GU: amenorrhea, clitoral enlargement, testicular atrophy

Metab: weight gain

Neuro: emotional lability, STROKE

Resp: INTRACRANIAL HYPERTENSIONPULMONARY EMBOLISM

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Endometriosis

Fibrocystic Breast Disease

Hereditary Angioedema

US Brand Names ⬆ ⬇

Danocrine

Action ⬆ ⬇

  • Inhibits pituitary output of gonadotropins, resulting in suppression of ovarian function. Has weak androgenic-anabolic activity.
Therapeutic effects:
  • Atrophy of ectopic endometrial tissue in endometriosis.
  • Decreased pain and nodularity in fibrocystic breast disease.
  • Correction of biochemical abnormalities in hereditary angioedema.

Classifications ⬆ ⬇

Therapeutic Classification: hormones

Pharmacologic Classification: androgens

Pharmacokinetics ⬆ ⬇

Absorption: Absorbed from the GI tract.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver.

Half-Life: 4.5 hr.

Canadian Brand Names ⬆ ⬇

Cyclomen

Time/Action Profile ⬆ ⬇

(disease response)

ROUTEONSETPEAKDURATION
PO (endometriosis)unknown6–8 wk60–90 days
PO (fibrocystic disease)1 mo2–6 mo1 yr
PO (angioedema)unknown1–3 mounknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

DA-na-zole

Code ⬆

NDC Code