oxacillin

Derm: rash, urticaria

GI: diarrhea, epigastric distress, nausea, vomiting, Clostridioides difficile-associated diarrhea (CDAD)

GU: interstitial nephritis

Hemat: eosinophilia, leukopenia

Local: pain at IM site, phlebitis at IV site

Neuro: SEIZURES

Misc: ANAPHYLAXIS AND SERUM SICKNESSALLERGIC REACTIONS INCLUDING , superinfection

Interactions ⬆ ⬇

Drug-drug:

Oxacillin may ↓ effectiveness of oral contraceptive agents.
Probenecid↓ renal excretion and ↑ blood levels of oxacillin (therapy may be combined for this purpose).
Concurrent use with methotrexate↓ methotrexate elimination and ↑ risk of serious toxicity.
Tetracyclinesmay ↓ effectiveness of oxacillin

Availability ⬆ ⬇

(Generic available)

Powder for injection: 1 g/vial; 2 g/vial; 10 g/vial

Route/Dosage ⬆ ⬇

IM IV (Adults and Children ≥40 kg): 250–2000 mg q 4–6 hr (up to 12 g/day).
IM IV (Children <40 kg): 100–200 mg/kg/day divided q 4–6 hr, maximum: 12 g/day.
IM IV (Neonates <1200 g): —50 mg/kg/day divided q 12 hr.
IM IV (Neonates ≥2 kg): —75 mg/kg/day divided q 8 hr for the first 7 days of life, then 100 mg/kg/day divided q 6 hr.
IM IV (Neonates 1.2–2 kg): —50 mg/kg/day divided q 12 hr for the first 7 days of life, then 75 mg/kg/day divided q 8 hr.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Bind to bacterial cell wall, leading to cell death. Not inactivated by penicillinase enzymes.

Therapeutic effects:

Bactericidal action.

Spectrum:

Active against most gram-positive aerobic cocci.
Spectrum is notable for activity against:
- Penicillinase-producing strains of Staphylococcus aureus,
- Staphylococcus epidermidis.
Not active against methicillin-resistant bacteria.

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: penicillinase resistant penicillins

Pharmacokinetics ⬆ ⬇

Absorption: Completely absorbed following IV administration; well absorbed from IM sites.

Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.

Protein Binding: 94% to albumin

Metabolism/Excretion: Partially metabolized by the liver (9%), partially excreted unchanged by the kidneys.

Half-Life: Neonates: 1.6 hr; Children up to 2 yr: 0.9–1.8 hr; Adults: 0.3–0.8 hr (↑ in severe hepatic impairment).

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
Oxacillin IM	rapid	30 min	4–6 hr
Oxacillin IV	rapid	end of infusion	4–6 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take medication around the clock and to finish the drug completely as directed, even if feeling better. Missed doses should be taken as soon as remembered. Advise patient that sharing of this medication may be dangerous.
Advise patient to report signs of superinfection (black, furry overgrowth on the tongue; vaginal itching or discharge; loose or foul-smelling stools) and allergy.
Instruct patient to notify health care professional if fever and diarrhea develop, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting health care professional.
Instruct patient to notify health care professional if symptoms do not improve.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0338- Baxter Healthcare Corporation
- 0338-1015- OXACILLIN
  - 0338-1015-41- 50 mL in 1 BAG (0338-1015-41)

25021- Sagent Pharmaceuticals
- 25021-146- Oxacillin
  - 25021-146-10- 10 VIAL in 1 CARTON (25021-146-10) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-162- Oxacillin
  - 25021-162-24- 10 VIAL in 1 CARTON (25021-162-24) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-163- Oxacillin
  - 25021-163-99- 10 BOTTLE in 1 CARTON (25021-163-99) / 100 mL in 1 BOTTLE

55150- Eugia US LLC
- 55150-127- Oxacillin
  - 55150-127-15- 10 VIAL in 1 BOX (55150-127-15) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL

55150- Eugia US LLC
- 55150-128- Oxacillin
  - 55150-128-24- 10 VIAL in 1 BOX (55150-128-24) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL

55150- Eugia US LLC
- 55150-129- Oxacillin
  - 55150-129-99- 1 VIAL, PHARMACY BULK PACKAGE in 1 BOX (55150-129-99) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

63323- Fresenius Kabi USA, LLC
- 63323-811- Oxacillin
  - 63323-811-00- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-811-00) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

63323- Fresenius Kabi USA, LLC
- 63323-812- Oxacillin
  - 63323-812-20- 10 VIAL, SINGLE-DOSE in 1 CARTON (63323-812-20) / 20 mL in 1 VIAL, SINGLE-DOSE (63323-812-01)

63323- Fresenius Kabi USA, LLC
- 63323-813- Oxacillin
  - 63323-813-20- 10 VIAL, SINGLE-DOSE in 1 CARTON (63323-813-20) / 20 mL in 1 VIAL, SINGLE-DOSE (63323-813-01)

64679- Wockhardt USA LLC.
- 64679-698- Oxacillin
  - 64679-698-01- 10 VIAL in 1 CARTON (64679-698-01) / 20 mL in 1 VIAL (64679-698-02)

64679- Wockhardt USA LLC.
- 64679-698- Oxacillin
  - 64679-698-03- 1 VIAL in 1 CARTON (64679-698-03) / 20 mL in 1 VIAL (64679-698-02)

64679- Wockhardt USA LLC.
- 64679-699- Oxacillin
  - 64679-699-01- 10 VIAL in 1 CARTON (64679-699-01) / 20 mL in 1 VIAL (64679-699-02)

64679- Wockhardt USA LLC.
- 64679-699- Oxacillin
  - 64679-699-03- 1 VIAL in 1 CARTON (64679-699-03) / 20 mL in 1 VIAL (64679-699-02)

64679- Wockhardt USA LLC.
- 64679-700- Oxacillin
  - 64679-700-01- 10 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (64679-700-01) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE (64679-700-02)

64679- Wockhardt USA LLC.
- 64679-700- Oxacillin
  - 64679-700-03- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (64679-700-03) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE (64679-700-02)

65862- Aurobindo Pharma Limited
- 65862-276-
  - 65862-276-37- 50 kg in 1 DRUM (65862-276-37)

66558- Fresenius Kabi iPSUM S.r.l.
- 66558-0203-
  - 66558-0203-0- 5 kg in 1 CONTAINER (66558-0203-0)

72485- Armas Pharmaceuticals Inc.
- 72485-409- Oxacillin
  - 72485-409-10- 10 VIAL in 1 CARTON (72485-409-10) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL (72485-409-01)

82449- Steriscience Specialties Private Limited
- 82449-506- oxacillin
  - 82449-506-02- 10 VIAL in 1 CARTON (82449-506-02) / 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇