secnidazole

Contraindicated in:

Hypersensitivity; cross-sensitivity with other imidazoles may occur;
Cockayne syndrome (↑ risk of hepatotoxicity and death);
Lactation: Lactation.

Use Cautiously in:

OB: Safety not established in pregnancy;
Pedi: Children <12 yr (safety and effectiveness not established).

GI: abdominal pain, diarrhea, metallic taste, nausea, vomiting

GU: vulvovaginal candidiasis, vulvovaginal pruritus

Neuro: headache

Drug-drug:

Alcohol or preparations containing ethanol or propylene glycol may lead to nausea, vomiting, diarrhea, abdominal pain, dizziness, and headache. Avoid use during secnidazole therapy and for ≥2 days after completing therapy.

Oral granules: 2 g/pkt

Bacterial Vaginosis

PO (Adults and Children ≥12 yr): 2 g as a single dose.

Trichomoniasis

PO (Adults and Children ≥12 yr): 2 g as a single dose. Any sexual partners should also be treated with a 2-g single dose.

Disrupts DNA synthesis in susceptible organisms.

Therapeutic effects:

Resolution of bacterial vaginosis.
Resolution of trichomoniasis.

Spectrum:

Active against Bacteroides spp., Gardnerella vaginalis, Prevotella spp., Mobiluncus spp., and Trichomonas vaginalis.

Therapeutic Classification: anti-infectives

Pharmacologic Classification: imidazoles

Absorption: Rapidly and completely absorbed following oral administration.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Primarily metabolized by CYP450 system in liver; 15% excreted unchanged in urine.

Half-Life: 17 hr.

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	rapid	4 hr	unknown

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
Advise patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care provider before taking other medications during therapy.
Advise patient to notify health care provider if signs and symptoms of vulvovaginal candidiasis (vaginal itching, white or yellowish discharge [discharge may be lumpy or look like cottage cheese]) occur. May require treatment with antifungal agents.
Advise patient to avoid alcohol during and for 2 days after last dose of secnidazole. May cause nausea, vomiting, diarrhea, abdominal pain, dizziness, and headache when taken with alcohol.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected. Advise female patient to avoid breastfeeding for ≥96 hr (4 days) following secnidazole dose.

NDC Code

11014- Catalent Pharma Solutions, LLC
- 11014-0236-
  - 11014-0236-3- 1 BAG in 1 DRUM (11014-0236-3) / 50000 g in 1 BAG

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-2008-
  - 14799-2008-1- 25 kg in 1 DRUM (14799-2008-1)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-2008-
  - 14799-2008-2- 10 kg in 1 DRUM (14799-2008-2)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-2008-
  14799-2008-3- 5 kg in 1 CAN (14799-2008-3)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-2008-
  14799-2008-4- 1 kg in 1 CAN (14799-2008-4)

49574- Hunan Jiudian Pharmaceutical Co.,Ltd.
- 49574-526-
  49574-526-01- 25 kg in 1 DRUM (49574-526-01)

49964- Corden Pharma Bergamo S.p.A.
- 49964-0047-
  49964-0047-0- 25 kg in 1 DRUM (49964-0047-0)

69751- Evofem Inc.
- 69751-400- Solosec
  69751-400-01- 1 PACKET in 1 CARTON (69751-400-01) / 2 g in 1 PACKET

71052- DARMERICA, LLC
- 71052-367-
  - 71052-367-01- 1000 g in 1 CONTAINER (71052-367-01)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-05- 5000 g in 1 CONTAINER (71052-367-05)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-10- 100 g in 1 CONTAINER (71052-367-10)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-20- 20000 g in 1 PACKAGE (71052-367-20)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-22- 25000 g in 1 PACKAGE (71052-367-22)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-25- 25 g in 1 CONTAINER (71052-367-25)

71052- DARMERICA, LLC
- 71052-367-
  71052-367-50- 500 g in 1 CONTAINER (71052-367-50)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-01- 1 g in 1 BAG (73212-110-01)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-05- 5 g in 1 BAG (73212-110-05)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-10- 10 g in 1 BAG (73212-110-10)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-11- 50 g in 1 BAG (73212-110-11)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-12- 100 g in 1 BAG (73212-110-12)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-13- 500 g in 1 BAG (73212-110-13)

73212- Qingdao Biopeptek Co., Ltd.
- 73212-110-
  73212-110-14- 1000 g in 1 BAG (73212-110-14)

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

Code ⬆