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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: palpitations, CARDIOVASCULAR COLLAPSE, hypertension, tachycardia

Derm: diaphoresis

GI: anorexia, dry mouth

GU: dysuria

Neuro: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, SEIZURES, weakness

Resp: respiratory difficulty

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Silfedrine Children's, Sudafed 12 Hour, Sudafed 24 Hour, Sudafed Children's, SudoGest, SudoGest 12 Hour

Action ⬆ ⬇

  • Stimulates alpha- and beta-adrenergic receptors.
  • Produces vasoconstriction in the respiratory tract mucosa (alpha-adrenergic stimulation) and possibly bronchodilation (beta2-adrenergic stimulation).
Therapeutic effects:
  • Reduction of nasal congestion, hyperemia, and swelling in nasal passages.

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies, nasal drying agents/decongestants

Pharmacologic Classification: adrenergics, alpha adrenergic agonists

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Appears to enter the CSF.

Metabolism/Excretion: Partially metabolized by the liver. 55–75% excreted unchanged by the kidneys (depends on urine pH).

Half-Life: Children: 3.1 hr; Adults: 9–16 hr (depends on urine pH).

Time/Action Profile ⬆ ⬇

(decongestant effects)

ROUTEONSETPEAKDURATION
PO15–30 minunknown4–6 hr
PO-ER60 minunknown12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

soo-doe-e-FED-rin

Code ⬆

NDC Code