- IV (Adults and Children >1 mo): 15–18 mg/kg in a single or divided dose (max loading dose = 20 mg/kg).
- IV (Neonates ): 15–20 mg/kg in a single dose. If clinically indicated, ≥15 min after completion of the initial loading dose, a 2nd loading dose may be administered over the subsequent 15 min as 20 mg/kg for term infants or 10–20 mg/kg for preterm infants.
Maintenance Anticonvulsant
- IV PO (Adults and Children >12 yr): 1–3 mg/kg/day in 1–2 divided doses.
- IV PO (Children >5 yr): 2–3 mg/kg/day in 1–2 divided doses.
- IV PO (Children ≤5 yr): 3–5 mg/kg/day in 1–2 divided doses.
Sedation
- PO IM (Adults ): 30–120 mg/day in 2–3 divided doses. Preoperative sedation: 100–200 mg IM 1–1.5 hr before the procedure.
- PO (Children ): 2 mg/kg 3 times daily. Preoperative sedation: 1–3 mg/kg PO/IM/IV 1–1.5 hr before the procedure.
Hypnotic
- PO SC IV IM (Adults ): 100–320 mg at bedtime.
- IV IM SC (Children ): 3–5 mg/kg at bedtime.
Hyperbilirubinemia
- PO (Adults ): 90–180 mg/day in 2–3 divided doses.
- PO (Children <12 yr): 3–8 mg/kg/day in 2–3 divided doses; doses up to 12 mg/kg/day have been used.
