- PO (Adults and Children ): 15–30 mg/kg/day as a single dose. Up to 60 mg/kg/day has been used in isoniazid-resistant TB (not to exceed 2 g/day as a single dose or 3 g/day in divided doses). May also be given as 50–70 mg/kg 2–3 times weekly (not to exceed 2 g/dose on daily regimen, 3 g/dose for 3-times-weekly regimen, or 4 g/dose for twice-weekly regimen). Patients with HIV: 20–40 mg/kg/day for 1st 2 mo of therapy (maximum: 2 g/day); further dosing depends on regimen used.
