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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision

GI: constipation, dry mouth, dyspepsia, nausea

Metab: heat intolerance

Neuro: confusion, dizziness, drowsiness, hallucinations, headache

Misc: ANGIOEDEMA

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hepatic Impairment

Action ⬆ ⬇

  • Acts as a muscarinic (cholinergic) receptor antagonist; antagonizes bladder smooth muscle contraction.
Therapeutic effects:
  • Decreased symptoms of overactive bladder.

Classifications ⬆ ⬇

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: anticholinergics

Pharmacokinetics ⬆ ⬇

Absorption: 15–19% absorbed.

Distribution: Unknown.

Protein Binding: 98%.

Metabolism/Excretion: Extensively metabolized in the liver by the CYP2D6 isoenzyme, with some metabolism by the CYP3A4 isoenzyme; the CYP2D6 isoenzyme exhibits genetic polymorphism (∼7% of population may be poor metabolizers and may have significantly ↑ darifenacin concentrations and an ↑ risk of adverse effects). 60% excreted by the kidneys as metabolites, 40% in feces as metabolites.

Half-Life: 13–19 hr.

Canadian Brand Names ⬆ ⬇

Enablex

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknown7 hr24 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

dar-i-FEN-a-sin

Code ⬆

NDC Code