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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: orthostatic hypotension, hypertension, peripheral edema, syncope

Derm: sweating

EENT: abnormal vision

GI: constipation, dry mouth, dyspepsia, nausea, vomiting

Neuro: dizziness, syncope, aggression, agitation, confusion, delirium, delusions, disorientation, drowsiness, dyskinesia, fatigue, hallucinations, headache, impulse control disorders (gambling, sexual, uncontrolled spending, binge/compulsive eating), insomnia, paranoid ideation, psychosis, SLEEP ATTACKS, somnolence, weakness

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Parkinson Disease

Renal Impairment

Restless Leg Syndrome

Renal Impairment

US Brand Names ⬆ ⬇

Requip, Requip XL

Action ⬆ ⬇

  • Stimulates dopamine receptors in the brain.
Therapeutic effects:
  • Decreased tremor and rigidity in Parkinson disease.
  • Decreased leg restlessness.

Classifications ⬆ ⬇

Therapeutic Classification: antiparkinson agents

Pharmacologic Classification: dopamine agonists

Pharmacokinetics ⬆ ⬇

Absorption: 55% absorbed following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Extensively metabolized by the liver primarily by the CYP1A2 isoenzyme; <10% excreted unchanged in urine.

Half-Life: 6 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknown8 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

roe-PIN-i-role

Code ⬆

NDC Code