Unresectable/Metastatic Melanoma, Non-Small Cell Lung Cancer, or Anaplastic Thyroid Cancer

• PO (Adults ): 2 mg once daily; continue until disease progression or unacceptable toxicity.

Adjuvant Treatment of Unresectable/Metastatic Melanoma

• PO (Adults ): 2 mg once daily; continue until disease recurrence or unacceptable toxicity for up to 1 yr.

Unresectable/Metastatic Solid Tumors

• PO (Adults ): 2 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and ≥51 kg): 2 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 38–50 kg): 1.5 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 26–37 kg): 1 mg once daily; continue until disease progression or unacceptable toxicity.

Low-Grade Glioma

• Oral Tablets
• PO (Children ≥1 yr and ≥51 kg): 2 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 38–50 kg): 1.5 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 26–37 kg): 1 mg once daily; continue until disease progression or unacceptable toxicity.
• Oral Solution
• PO (Children ≥1 yr and ≥51 kg): 2 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 46–50 kg): 1.6 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 42–45 kg): 1.4 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 38–41 kg): 1.25 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 34–47 kg): 1.15 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 30–33 kg): 1 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 26–29 kg): 0.9 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 22–25 kg): 0.85 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 18–21 kg): 0.7 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 14–17 kg): 0.55 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 12–13 kg): 0.45 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 11 kg): 0.4 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 9–10 kg): 0.35 mg once daily; continue until disease progression or unacceptable toxicity.
• PO (Children ≥1 yr and 8 kg): 0.3 mg once daily; continue until disease progression or unacceptable toxicity.