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Indications ⬇

High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

GI: diarrhea, nausea, vomiting

Hemat: BLEEDING

Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hepatic Impairment

Action ⬆ ⬇

  • Inhibits thrombin by binding to its receptor sites. Inhibition of thrombin prevents activation of factors V, VIII, and XII; the conversion of fibrinogen to fibrin; platelet adhesion and aggregation.
Therapeutic effects:
  • Decreased thrombus formation and extension with decreased sequelae of thrombosis (emboli, postphlebitic syndromes).

Classifications ⬆ ⬇

Therapeutic Classification: anticoagulants

Pharmacologic Classification: thrombin inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver; excreted primarily in feces via biliary excretion. 16% excreted unchanged in urine; 14% excreted unchanged in feces.

Half-Life: 39–51 min (↑ in hepatic impairment).

Time/Action Profile ⬆ ⬇

(anticoagulant effect)

ROUTEONSETPEAKDURATION
IVimmediate1–3 hr2–4 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

ar-GAT-tro-ban

Code ⬆

NDC Code