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Indications ⬇

High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: alopecia

EENT: ototoxicity, tinnitus

F and E: hypocalcemia, hypokalemia, hypomagnesemia

GI: nausea, vomiting, diarrhea, HEPATOTOXICITY

GU: nephrotoxicity, sterility

Hemat: anemia, LEUKOPENIA, THROMBOCYTOPENIA

Local: phlebitis at IV site

Metab: hyperuricemia

Neuro: malaise, peripheral neuropathy, REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME (RPLS), SEIZURES, weakness

Misc: ANAPHYLAXIS

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Platinol

Action ⬆ ⬇

  • Inhibits DNA synthesis by producing cross-linking of parent DNA strands (cell-cycle phase-nonspecific).
Therapeutic effects:
  • Death of rapidly replicating cells, particularly malignant ones.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: alkylating agents

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed; accumulates for months.

Metabolism/Excretion: Excreted mainly by the kidneys.

Half-Life: 30–100 hr.

Time/Action Profile ⬆ ⬇

(effects on blood counts)

ROUTEONSETPEAKDURATION
IVunknown18–23 days39 days

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

sis-PLA-tin

Code ⬆

NDC Code