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Indications ⬇

BEERS REMS

Unlabeled Use:
  • Single-dose treatment for atrial fibrillation.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: conduction disturbances, angina, bradycardia, hypotension, SUPRAVENTRICULAR ARRHYTHMIAS, VENTRICULAR ARRHYTHMIAS

Derm: rash

EENT: blurred vision

GI: altered taste, constipation, nausea, vomiting, diarrhea, dry mouth

Hemat: AGRANULOCYTOSIS

MS: joint pain

Neuro: dizziness, shaking, weakness

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Rythmol SR

Action ⬆ ⬇

  • Slows conduction in cardiac tissue by altering transport of ions across cell membranes.
Therapeutic effects:
  • Suppression of ventricular arrhythmias.
  • Prolonged time to recurrence of symptomatic paroxysmal atrial arrhythmias, including paroxysmal atrial fibrillation/flutter and paroxysmal supraventricular tachycardia.

Classifications ⬆ ⬇

Therapeutic Classification: antiarrhythmics (class IC)

Pharmacokinetics ⬆ ⬇

Absorption: 3–11% absorbed following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Extensively metabolized by the liver by the CYP1A2, CYP2D6, and CYP3A4 isoenzymes (some metabolites have antiarrhythmic activity); the CYP2D6 isoenzyme exhibits genetic polymorphism (∼7% of population may be poor metabolizers and may have significantly ↑ propafenone concentrations and an ↑ risk of adverse effects). .

Half-Life: Extensive metabolizers: 2–10 hr; Slow metabolizers: 10–32 hr.

Canadian Brand Names ⬆ ⬇

Rythmol

Time/Action Profile ⬆ ⬇

(antiarrhythmic effects)

ROUTEONSETPEAKDURATION
POhr–days4–5 days‡hr

‡Chronic dosing.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

pro-PAF-en-one

Code ⬆

NDC Code