Granules for oral suspensionberry flavor: 40 mg/mL
Tablets: 200 mg
Route/Dosage⬆⬇
PO (Adults ): 200 mg twice daily for 10 days.
PO (Children ≥6 mo and ≥12.5 kg): Tablets: 200 mg twice daily for 10 days (if unable to swallow tablets, use granules for oral suspension).
PO (Children ≥6 mo and 9–<12.5 kg): Granules for oral suspension: 160 mg twice daily for 10 days.
PO (Children ≥6 mo and 7–<9 kg): Granules for oral suspension: 120 mg twice daily for 10 days.
PO (Children ≥6 mo and 4–<7 kg): Granules for oral suspension: 80 mg twice daily for 10 days.
US Brand Names⬆⬇
Dificid
Action⬆⬇
Bactericidal action mostly against clostridia; inhibits RNA synthesis.
Acts locally in the GI tract to eliminate Clostridioides difficile.
Therapeutic effects:
Elimination of diarrhea caused by Clostridioides difficile.
Classifications⬆⬇
Therapeutic Classification: anti-infectives
Pharmacologic Classification: macrolides
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption.
Distribution: Stays primarily in the GI tract.
Metabolism/Excretion: Mostly transformed via hydrolysis in the GI tract to OP-1118, its active metabolite. Eliminated mostly (>92%) in feces: <1% excreted in urine.
Instruct patient to take fidaxomicin twice daily, 12 hr apart, as directed for the full course of therapy, even if feeling better. Skipping doses or not completing full course of therapy may ↓ effectiveness of therapy and ↑ risk that bacteria will develop resistance and not be treatable in the future.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Pronunciation⬆⬇
fi-dax-oh-MYE-sin
Code⬆
NDC Code
0480- Teva Pharmaceuticals, Inc.
0480-2596- Fidaxomicin
0480-2596-34- 20 TABLET, FILM COATED in 1 BOTTLE (0480-2596-34)
52015- Merck Sharp & Dohme LLC
52015-080- Dificid
52015-080-01- 1 BOTTLE in 1 CARTON (52015-080-01) / 20 TABLET, FILM COATED in 1 BOTTLE
52015- Merck Sharp & Dohme LLC
52015-700- DIFICID
52015-700-22- 1 POUCH in 1 CARTON (52015-700-22) / 1 BOTTLE, GLASS in 1 POUCH (52015-700-23) / 150 mL in 1 BOTTLE, GLASS (52015-700-21)
55500- North China Pharmaceutical Huasheng Co. Ltd.
