section name header

Indications ⬇

High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: alopecia, rash

EENT: ototoxicity

F and E: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia

GI: abdominal pain, nausea, vomiting, constipation, diarrhea, hepatitis, stomatitis

GU: gonadal suppression, nephrotoxicity

Hemat: ANEMIA, LEUKOPENIA, THROMBOCYTOPENIA

Metab: hyperuricemia

Neuro: peripheral neuropathy, weakness

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Paraplatin,

Action ⬆ ⬇

  • Inhibits DNA synthesis by producing cross-linking of parent DNA strands (cell-cycle phase-nonspecific).
Therapeutic effects:
  • Death of rapidly replicating cells, particularly malignant ones.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: alkylating agents

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Well distributed to tissues.

Protein Binding: Platinum is irreversibly bound to plasma proteins.

Metabolism/Excretion: Excreted mostly by the kidneys.

Half-Life: Carboplatin: 2.6–5.9 hr (↑ in renal impairment); platinum: 5 days.

Time/Action Profile ⬆ ⬇

( effects on blood counts)

ROUTEONSETPEAKDURATION
IVunknown21 days28 days

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

kar-boe-PLA-tin

Code ⬆

NDC Code